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Suchang Song, Principal Researcher Team, Center for Biomaterials Research, KIST, published an international journal ‘Small’
A bioprinting ink has been developed that can create structures for artificial tissues only by controlling the temperature without a curing process that can cause cytotoxicity.
The Korea Institute of Science and Technology announced on the 2nd that a research team led by Song Soo-chang, a senior researcher at the Center for Biomaterials, developed a bio-ink that stably induces the structure and induces tissue regeneration only by temperature control, and then biodegrades following a certain period of time.
Bio-ink is a material for realizing a three-dimensional (3D) artificial tissue structure using cells and biomaterials and is used in 3D bioprinting technology.
Bioink is printed to make 3D scaffolds, and cultured cells are put into artificial tissues to create artificial tissues. However, there was a problem that the ‘photocuring’ process, in which a chemical crosslinking agent is added and ultraviolet rays are applied to harden the scaffold, can cause cytotoxicity.
The research team developed an ink that eliminates the photocuring process by using temperature-sensitive polyphosphazene hydrogel, which exists in liquid form at low temperatures but changes to a hard gel at body temperature.
The research team explained that this material also has the advantage of preserving growth factors, which are proteins that help in tissue regeneration, for a long time.
The research team implanted a three-dimensional scaffold printed by mixing bone regeneration growth factor and the developed bioink into the damaged bone area of a mouse, and as a result, the bone was regenerated to a normal tissue level, and the transplanted scaffold slowly biodegraded in the body over 42 days. Explained.
The bio-ink developed this time was transferred to bio-venture ‘NexGel Biotech’ in June of last year, and products such as bone graft materials are being developed, the research team added.
Senior researcher Song said, “We are conducting follow-up research to apply different physical characteristics of the ink to the regeneration of other tissues besides bone tissue,” and added, “We expect to finally be able to commercialize bio-ink tailored to tissues and organs for each part.” said.
The research results were published as a cover paper in the latest issue of ‘Small’, an international academic journal.
/yunhap news
