IVF, Endometriosis, & Tubal Patency: A Retrospective Study

IVF, Endometriosis, & Tubal Patency: A Retrospective Study

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HSG adn Endometrioma: Unveiling Insights for IVF Success

A recent retrospective study from istanbul, Türkiye, sheds light on the role of Hysterosalpingography (HSG) in evaluating women with endometriomas undergoing In Vitro Fertilization (IVF). This article delves into the study’s methodology,findings,and implications for women in the United States facing similar fertility challenges.

Understanding the Study: Endometrioma, HSG, and IVF

Between January 2015 and December 2021, researchers at Acibadem Maslak Hospital IVF Center in Istanbul meticulously reviewed the cases of women aged 20 to 40.All participants had been diagnosed with endometriomas—ovarian cysts associated with endometriosis—and had undergone HSG as part of their IVF workup. The study, approved by the Institutional Review Board and ethics Committee of Acibadem Mehmet Ali Aydinlar University (ATADEK-2021/21 − 19), aimed to understand the connection between these factors.

To ensure a focused analysis, the study excluded women over 40 to minimize the potential influence of embryonic aneuploidy (chromosomal abnormalities in the embryo). A strict set of inclusion and exclusion criteria were established. women with a history of pelvic surgery, pelvic inflammatory disease, or pelvic tuberculosis were excluded.Moreover, individuals with conditions known to substantially impact IVF outcomes, such as polycystic ovarian syndrome (PCOS), diminished ovarian reserve, uterine abnormalities (septate, unicornuate, bicornuate, didelphus uterus) Asherman’s syndrome, thin endometrium, recurrent IVF failure and male infertility factors like azoospermia and criptozoospermia were also excluded.

The Role of Transvaginal Ultrasound (USG) in Diagnosing Endometrioma

Transvaginal ultrasound (USG) played a crucial role in diagnosing endometriomas. The criteria included identifying ovarian benign tumors characterized by a circular appearance, a thickened enclosure, a smooth outer rim, and a homogenous, slightly liquid internal echo. As noted in research, this aligns with established diagnostic criteria.

While MRI is another imaging technique,studies suggest that USG offers comparable diagnostic accuracy.Further supporting this, research indicates that USG’s diagnostic rates are similar to those of surgical techniques, considered the gold standard, especially for identifying endometriosis affecting the ovaries, bladder, and bowel.

HSG Procedure: A Key Step in Fertility Evaluation

HSG, a vital diagnostic tool, was performed on all participants as part of their standard fertility assessment. This procedure involves injecting a contrast dye into the uterus and fallopian tubes,allowing doctors to visualize the anatomy and identify any blockages or abnormalities. Before the HSG, a detailed medical history was taken, inquiring about the patient’s last menstrual period, the presence of an intrauterine device (IUD), signs of pelvic infection, allergies, and the possibility of pregnancy.

During the procedure,a speculum was inserted into the vagina,followed by disinfection with povidone-iodine with the patient in the lithotomy position. A 5-F flexible balloon catheter, inflated with saline, was then carefully placed into the cervical canal. Generally,anesthesia is not routinely administered for HSG. A non-ionic, water-soluble contrast material was chosen to minimize the risk of allergic reactions. Real-time fluoroscopy was used to guide the HSG, with spot X-ray images taken during the process. Hydrosalpinx, a fluid-filled expansion of the fallopian tube, was documented when observed. The estimated average radiation dose to the ovaries was 2.7 mGy, with an effective dose of 1.2 mSv.

Post-procedure,patients were prescribed doxycycline 100 mg twice daily for five days as a preventative measure. Nonsteroidal anti-inflammatory drugs (NSAIDs) were recommended for pain relief,if needed. To ensure consistency and reduce potential bias, one IVF specialist (BT) meticulously evaluated all HSG images. Key indicators of tubal pathology included:

  1. dilated fallopian tube with complete or partial contrast filling but lack of spill from the tube to pelvic or abdominal cavity.
  2. loculated contrast spill or pooling collections of spilled contrast.

Laparoscopy: Confirming Tubal Pathologies

Laparoscopy,considered to be the gold standard for tubal evaluation,was conducted on patients with suspected hydrosalpinx identified during HSG. During laparoscopy, transcervical-intrauterine methylene blue was applied, and a unilateral or bilateral proximal tubal occlusion was performed to the proximal tuba on the sides where hydrosalpinx was confirmed.

Statistical Analysis and Findings

A rigorous statistical analysis was performed using SPSS software [Version 22.0; SPSS Inc., Chicago, IL, USA]. The data was thoroughly examined to identify notable correlations between HSG findings and IVF outcomes.

HSG in the

What are the key takeaways from this study for advancing fertility assessments in the future?

Interview: HSG and Endometrioma – Enhancing IVF Success

Understanding the HSG’s crucial role in Fertility Treatment

Archyde News: Welcome,Dr. Anya Sharma, to Archyde News. We’re analyzing a recent study from Turkey regarding the use of HSG in evaluating women with endometriomas undergoing IVF. Could you briefly explain what HSG is and why it’s crucial?

Dr. Sharma: Thank you for having me. HSG, or Hysterosalpingography, is an X-ray procedure used to visualize the uterus and fallopian tubes. It’s a key diagnostic tool in fertility assessments, helping us identify blockages or abnormalities that could impact fertility, especially for women with endometriomas considering IVF.

The HSG Procedure and Endometrioma Diagnosis

Archyde News: The study mentions both the diagnosis of endometriomas using transvaginal ultrasound and the use of HSG. How do these two procedures complement each other?

Dr.Sharma: Transvaginal ultrasound (USG) helps in the initial diagnosis, assessing for the presence of ovarian cysts and the appearance that may be associated with endometriomas.The HSG than examines the fallopian tubes, assessing their patency, the main function being allowing the passage for the egg. Both are essential during a fertility workup.

The Study’s Methodology and Patient Considerations

Archyde News: the study excluded women over 40. How does age affect HSG and IVF outcomes?

Dr.sharma: The study excluded certain criteria to make sure the results are focused.As women age they could have higher chances of chromosomal abnormalities in the embryo. The timing is critically important,. The best time to have an HSG, mentioned by IVF Florida, is during days 5-10 of the menstrual cycle, to ensure the least chance of pregnancy, and of course, to get the most accurate results.

HSG and Laparoscopy: An In-depth Analysis

Archyde News: The article mentions that laparoscopy is considered the gold standard. In what situations is laparoscopy performed after an HSG?

Dr. Sharma: laparoscopy is often considered when HSG reveals abnormalities, such as hydrosalpinx and other tubal pathologies or blockages. it allows for more in-depth evaluation and potential surgical intervention, like tubal occlusion if hydrosalpinx is confirmed.

Implications for women Undergoing IVF

Archyde News: How can the study’s findings on HSG and endometriomas impact the approach to IVF treatment for women in the U.S. or other regions?

dr. Sharma: The study reinforces the importance of thorough pre-IVF evaluation, particularly in women with endometriomas. Understanding tubal patency and the presence of hydrosalpinx, using HSG, can guide treatment strategies. Such as, if meaningful tubal issues are identified, IVF specialists might adapt the approach to optimize success, like considering salpingectomy.

Post-Procedure Care and Prevention

Archyde News: From a clinical viewpoint, what post-HSG care and preventative measures are typically recommended?

Dr. Sharma: Post-HSG, antibiotics, like doxycycline, are commonly prescribed to prevent infection. Nonsteroidal anti-inflammatory drugs (NSAIDs) are usually prescribed to manage any discomfort. Women are advised on what to look for in signs of complication.

The Future of Fertility Diagnostics

Archyde News: What are the key takeaways from this study for advancing fertility assessments in the future? And Is there anything else you’d like to add?

Dr.Sharma: the study underscores the role of the HSG as an essential, reliable test. . Advancements in imaging techniques and personalized medicine approaches may further refine these diagnostics and improve outcomes further, .

Reader Engagement

Archyde News: dr. Sharma, thank you for sharing your expertise. To our readers: What further questions do you have about the role of HSG in IVF treatment? Share your thoughts in the comments below!

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