Intestinal bacteria make you resistant to high blood pressure medication
high blood pressure is a widespread problem in society, with some sufferers suffering from treatment-resistant hypertension To suffer. The reason for such resistance to therapy has so far remained unclear, but recent research shows that a specific gut bacterium plays an important role.
In a recent study involving the University of Toledo was found that the intestinal bacterium Coprococcus comes to resistance to so-called ACE inhibitors contributes, which are commonly used to treat high blood pressure. the study results were at the annual meeting of American Society for Pharmacology and Experimental Therapeutics presented.
Gut flora can affect drug metabolism
It was already known that microorganisms in the gut (gut microbiota) release a variety of enzymes that affect drug metabolism can, the researchers report.
In the new study, the team has now examined the connection between the composition of the gut microbiome (gut flora), enzymatic activity and the effectiveness of ACE inhibitors. In addition to sartans, ACE inhibitors form the most important medicines to treat high blood pressure.
To find out if the gut microbiota plays a role in blood pressure drug resistance, the experts gave rats with high blood pressure a single dose of a ACE-Hemmers.
Special intestinal bacteria crucial
The drug was found to be more effective at lowering blood pressure in hypertensive rats with a lower burden on the gut microbiome. A special bacterium called Coprococcus comes contributes, however Resistance to ACE inhibitors the experts report.
In additional experiments, the team found that Coprococcus comes is actually able to break down the ACE inhibitor (quinapril) used. The experts also found that giving the bacterium together with quinapril in hypertensive rats reduced blood pressure less than when the ACE inhibitor was given alone.
Determine antihypertensive drugs not suitable for everyone
„We are still in the early stages of studying the interactions between gut bacteria and antihypertensive drugs. However, our current results suggest that the same drug may not be appropriate for every human being, as each human has a unique composition of the gut microbiome with a unique profile of enzyme activities“, so Dr. Tao Yang | of the University of Toledo.
„Today, doctors treat resistant high blood pressure by adding or substituting drugs, which can lead to overdose, more side effects, and poor adherence to therapy“, adds the study author in one press release.
A better understanding of the relationship between gut microbiota and drug efficacy may enable new approaches to treating people who are unresponsive to currently available antihypertensive drugs.
According to the expert, such treatment approaches might new drugs or the Modulation der Darmmikrobiota with probiotics, antibiotics and other methods.
The team is already conducting further research into other types of gut bacteria and blood pressure drugs to identify the mechanism by which gut microbiota influence the effectiveness of antihypertensive drugs. (as)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Swell:
- American Society for Pharmacology and Experimental Therapeutics: Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors (veröffentlicht 05.04.2022), American Society for Pharmacology and Experimental Therapeutics
- Experimental Biology: Gut bacteria may contribute to blood pressure medicine resistance (veröffentlicht 05.04.2022), Experimental Biology
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.
