2023-09-07 15:30:20
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Alzheimer’s: intermittent fasting to set the clock straight?
A new animal study published in the journal Cell Metabolism highlights the promising role of chrononutrition in the management of Alzheimer’s disease.
The Alzheimer’s disease is a complex pathology which researchers are still trying to understand. understand the mechanisms. Some are linked to circadian cycle disruptions (our biological clock), disorders which affect more than 80% of Alzheimer’s patients and result in particular in a disturbed sleep or twilight syndrome (sundowning in English), a form of restlessness that can affect sufferers at sunset. What research is gradually discovering is that far from being just a symptom of Alzheimer’s, these circadian disruptions are also involved in the genesis or development of the disease. This discovery is more than essential, because there are ways to reset our biological clock. Among them, time-limited feeding (time-restricted feeding), more commonly called “ intermittent fasting “, seems very promising according to a new American study carried out on mice presenting Alzheimer-like symptoms.
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Indeed, according to the results obtained by the American scientific team, mice who were given a restricted time window for eating showed notable cognitive improvements compared to those who had permanent access to food. They showed better memory, reduced nighttime activity, more regular sleep schedule and less disruption during sleep. Additionally, cognitive assessments revealed that these mice had fewer behavioral symptoms associated with Alzheimer’s disease. Furthermore, the results were also encouraging at the physiological level. Mice subjected to intermittent fasting showed different expression of many genes associated with Alzheimer’s disease and neuroinflammation, as well as reduction of the accumulation of amyloid proteins in the brain.
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If, for the moment, these conclusions, although encouraging, have not yet been verified in humans, the authors are hopeful that their results will be confirmed in human clinical trials.
« Time-Restricted Eating is a strategy that people can easily and immediately incorporate into their lives », Recalls Paula Desplats, professor in the department of neuroscience at the school of medicine at the University of California at San Diego and lead author of the study. “ If we can replicate our results in humans, this approach could be a simple way to significantly improve the lives of people with Alzheimer’s disease and those who care for them. »
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