2023-07-03 20:10:00
Studies have shown that chronic inflammatory bowel disease increases the risk of spinal fractures. The risk of fracture increased by up to 1.6 times.
Long-term use of steroids, etc., has been affected, and experts suggest that vitamin D supplementation therapy should be reviewed along with continuous monitoring.
A large study has found that inflammatory bowel disease increases the risk of spinal fractures.
The results of a large-scale study on the association between inflammatory bowel disease and spinal fractures will be published on the 17th in the Journal of Korean Medical Science, an international journal of the Korean Medical Association.
Inflammatory bowel diseases represented by Crohn’s disease and ulcerative colitis have been reported to cause various complications in that they cause malabsorption due to chronic intestinal diseases.
In particular, there is a warning voice that the risk of osteoporosis or fractures may increase in that it causes deficiencies in iron, zinc, calcium, and vitamin D.
However, there was a lack of evidence on whether inflammatory bowel disease actually affects these fractures.
This is why the research team led by Professor Lee Jun-seok of the Catholic University of Medicine conducted a large-scale follow-up study on actual domestic patients.
Accordingly, the research team compared and analyzed 33,778 patients with inflammatory bowel disease and 101,265 controls from 2008 to 2018.
As a result, a total of 559 vertebral fractures occurred among inflammatory bowel disease patients during the study period. There were 444 cases of Crohn’s disease and 115 cases of ulcerative colitis.
Analysis of fracture risk in patients with inflammatory bowel disease associated with steroid use
Statistically, during the follow-up period, the vertebral fracture incidence (IRR) of patients with inflammatory bowel disease was 1.27 per 1000 per person/year, which was significantly higher than that of the control group.
Among inflammatory bowel diseases, Crohn’s disease was more influential in vertebral fractures. In fact, as a result of the multivariate analysis, Crohn’s disease patients had a 1.59 times higher risk of vertebral fractures than the control group.
In addition, patients with ulcerative colitis were found to have a 1.26-fold increased risk of spinal fracture compared to healthy people.
This tendency was higher in older age, in women than in men, and the longer the duration of steroid use.
The severity of vertebral fractures also showed a similar trend. Even following excluding all other factors through Cox regression analysis, Crohn’s disease patients were 1.82 times more likely to be exposed to severe or more vertebral fractures than the general population.
Similarly, patients with ulcerative colitis had a 1.49-fold higher risk of severe vertebral fracture compared to healthy individuals.
The main factor for this was also the long-term use of steroids. This is because patients who were prescribed steroids for longer for the treatment of inflammatory bowel disease had a higher risk of fracture.
“Inflammatory bowel disease significantly increased the risk of vertebral fractures, and this tendency was stronger in the elderly, women, and patients who were prescribed steroids for a long time,” said the research team. “In the case of patients with inflammatory bowel disease, This suggests that vitamin D supplementation therapy should be implemented along with monitoring.”
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