[의학신문·일간보사=이상만 기자] A method has been found to increase the drug delivery rate and increase the effectiveness of treatment for intractable brain tumors.
Department of Medical Engineering, Yonsei University College of Medicine, Seong Hak-Jun∙Shin Young-min∙Professor Yoo Seung-eun, Sewoom Baek Researcher(PhD) The research team devised a method to enhance the effect of brain tumor drugs and confirmed the actual efficacy in the spheroids that caused brain tumors. 11day said.
The results of this study were published in a world-renowned academic journal in the field of materials science. ‘Advanced Healthcare Materials(Advanced Healthcare Materials, IF 9.933)’ published in the latest issue.
total brain tumor 15%Glioblastoma is a disease in which tumors develop in glial cells in the brain.. World Health Organization(WHO)divided according to tumor malignancy 4Worst in dog rating 4It is difficult to treat as it belongs to the grade.
Convulsions depending on the location of the brain where the glioblastoma occurred, language∙Various symptoms such as visual impairment. The faster the tumor grows, the faster the symptoms worsen.. Headache when intracranial pressure rises rapidly as symptoms worsen, throw up, loss of consciousness occurs.
surgery for treatment, radiation, drugs, etc.. Glioblastoma rapidly develops drug resistance. The tumor is deprived of oxygen inside due to cell division, and the hypoxic state leads to the expression of genes that make them resistant to anticancer drugs.
To solve this problem, the research team devised a way to supply oxygen to glioblastoma and made a spheroid that reproduced glioblastoma as it is to test the actual efficacy..
first, Since the hypoxic state caused by tumor cell division lowers the drug response, we created a plan to increase oxygen supply by using oxygen-releasing microparticles.. Microparticles have a size 0.1~100 particles down to the micrometer.
When a small amount of hydrogen peroxide is administered along with microparticles to the tumor surface, a chemical reaction occurs, resulting in the continuous generation of sufficient oxygen..
In order to confirm the actual effect, the production of spheroids transferred with glioblastoma was continued.. A spheroid is a group of dozens or more of single cells. 3It is a dimensional sphere-shaped aggregate.
As a result of treating spheroids with oxygen-releasing microparticles, The invasiveness, which indicates the extent to which the tumor spreads compared to untreated spheroids, is 58% was low. drug reactivity 32% increased.
In addition, glioblastoma with sufficient oxygen and glioblastoma spheroids without 3D It was made from a chip and implanted in each mouse.. In the oxygen-sufficient model, the tumor growth rate was lower than in the control group. 57% slow and drug responsive 19% was high.
Professor Seong Hak-jun “This spheroid can also be used in animal experiments, so it can be used in various ways to conquer glioblastoma, such as testing drug response.”as “In addition to glioblastoma, we will continue to develop a platform that reproduces the tumor environment to take the lead in overcoming intractable diseases.”said.