2023-08-20 03:00:00
06:00 AM Sunday 20 August 2023
Scientists say they have found a way to identify early warning signs of vascular disease from a simple saliva sample.
A team of scientists used a simple mouthwash to see if levels of white blood cells were an indicator of gingivitis in the saliva of healthy adults and might be linked to warning signs of cardiovascular disease.
They found that higher levels were associated with poor flow-mediated dilation, which is an indicator of poor arterial health.
“Even in healthy young adults, low levels of oral inflammatory load may have an impact on cardiovascular health, which is one of the leading causes of death in North America,” said Dr Trevor King of Mount Royal University, corresponding author of the study published in Frontiers in Oral Health. .
King and colleagues set out to study healthy young men currently without diagnosed gum problems to determine whether lower levels of stomatitis might be clinically relevant to cardiovascular health.
“We’re starting to see more relationships between oral health and cardiovascular disease risk,” said Ker Young Hong, first author of the study, who is now studying dentistry at the University of Western Ontario. even in healthy individuals, this comprehensive approach might be implemented earlier.”
The team selected pulse wave velocity, which can measure arterial stiffness, and flow-mediated dilatation, which is a measure of how well arteries are able to dilate to allow greater blood flow, as key predictors of cardiovascular risk.
The scientists recruited 28 non-smoking participants between the ages of 18 and 30, with no comorbidities or medications that might affect cardiovascular risk, and no history of periodontal disease reported.
They were asked to fast for six hours, excluding drinking water, before visiting the lab.
In the lab, participants rinse their mouths with water before rinsing them with saline solution collected for analysis.
The participants then lay down for 10 minutes to perform an electrocardiogram, and remained lying down for another 10 minutes so that scientists might measure blood pressure, flow-mediated dilatation, and pulse wave velocity.
The scientists found that a higher number of white blood cells in saliva was significantly related to poor flow-mediated dilation, suggesting that these people may be at a higher risk of developing cardiovascular disease. However, there was no relationship between white blood cells and pulse wave velocity, so long-term effects on arterial health had not occurred yet.
The scientists hypothesized that inflammation from the mouth, and leakage into the vascular system, affects the ability of the arteries to produce nitric oxide, which allows them to respond to changes in blood flow.
Elevated levels of white blood cells can have a greater effect on vascular weakness. The levels found in the participants are usually not considered clinically significant.
King concluded: “Optimal oral hygiene is always recommended in addition to regular visits to the dentist, especially in light of this evidence. However, this study was a pilot study. We hope to increase the study population and explore these findings. We also hope to include more individuals with gingivitis and periodontitis.” The more advanced age to more deeply understand the effect of different levels of periodontitis on the heart and blood vessels.”
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