Scientists have created a map of human skin that provides the ‘recipe’ for creating skin.
The researchers say the findings could be used to create new hair follicles and skin grafts for people with burns.
This study reveals how human skin is formed.
Researchers have mapped human skin cells for the first time to determine how skin is formed before birth and what defects in skin formation occur during disease.
Before birth, the skin has a unique ability to heal without scarring.
A team from the Wellcome Sanger Institute and Newcastle University also developed a small piece of skin in a dish capable of growing hair.
Using this organoid, they demonstrated that immune cells play an important role in scar-free skin repair, which may make it possible to prevent scar formation after surgery, or to heal wounds without scarring. go
“We have provided the first molecular ‘recipe’ for making human skin using a prenatal human skin atlas and found that before birth, human hair follicles are formed,” says co-author Dr. Elena Winheim of the Wellcome-Senger Institute. How are they made?
‘The clinical potential of these findings is very bright and could be used in regenerative medicine, such as during skin and hair transplantation, especially for burn victims or people with alopecia areata.’
The skin is the largest organ of the human body, measuring an average of two square meters, and provides a protective shield, regulates body temperature and can regenerate itself.
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Skin development occurs in the sterile environment of the womb, in which all hair follicles form before birth.
It has been very difficult to study how human skin is formed, because animal models are fundamentally different.
As part of the Human Cell Atlas, which is mapping all cell types in the human body.
A team of researchers is focusing on studying how human skin is formed.
Professor Muzalfah Hanifa, Interim Head of Cellular Genetics at the Wellcome Sanger Institute, said: ‘Our prenatal human skin atlas and organoid model provide the research community with a freely available resource to study congenital skin diseases and explore the potential of regenerative medicine. provide
‘We are making exciting progress towards creating human cell atlases, understanding the biological stages of human body formation and investigating disorders in disease.
These results have been published in the journal Nature.
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