2023-05-20 15:54:47
“Hepatocytes also affect the peripheral biological clock”… Discovered through chimera mouse experiments
Research has shown that liver cells, in addition to the brain, act as the main body of the biological clock.
The joint research team, including the French National Center for Scientific Research (CNRS), announced that this was the result of an animal experiment targeting mice (chimera mice) that have livers transplanted with human liver cells.
The biological clock (biological clock) corresponds to the control tower that controls not only the physical rhythms (sleep and wakefulness) of humans, animals, plants, and microorganisms, but also the emotional rhythms (moods and emotions) and intellectual rhythms (thinking and judgment).
According to the biological clock theory so far, the ‘central biological clock’ in the brain controls (synchronizes) the circadian clock of the ‘peripheral biological clock’ in each organ of the body. Only the ‘suprachiasmatic nuclei (SCN)’ belonging to a group of brain cells has been known to synchronize the circadian cycle (24-hour cycle) of mammals and the like.
Poor liver can increase the risk of metabolic syndrome such as obesity, high blood pressure, high cholesterol, and diabetes
However, the research team found that not only brain cells but also liver cells affect the peripheral biological clock. As a result of the study, it was found that the circadian cycle of nocturnal mice transplanted with human hepatocytes was shortened by 2 hours, similar to that of humans. The research team analyzed that these changes were caused by human liver cells. Human liver cells can influence the entire rhythmic physiology of animals, including the peripheral circadian clocks in each organ of the body.
The research team said, “Changes in the peripheral circadian clock caused by liver diseases such as cirrhosis can alter the synchronization function of the central circadian clock.” If the liver deteriorates, it adversely affects the metabolism of the whole body, suggesting that there is a risk of increasing the risk of metabolic syndrome (obesity, high blood pressure, high cholesterol, diabetes). Paris City University in France and the University of Queensland in Australia also participated in the study.
The results of this study (Liver cells control our biological clock) were published in the international journal Science Advances.
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