2023-06-13 01:31:00
Studies have shown that intramuscular and oral high-dose vitamin D therapy is not effective in preventing fractures or falls. Through this study, it was found that high-dose vitamin D therapy might rather increase the risk of falls, and opinions emerged that a new concept and definition of vitamin D intake was needed.
Professor Myeong Seung-kwon, dean of the International Cancer Graduate School at the National Cancer Center, announced on the 12th that he had confirmed these results as a result of a meta-analysis of 15 clinical trials published in international journals between 1992 and 2021.
High-dose vitamin D therapy is not effective in preventing fractures and falls | Source: Getty Image Bank
Vitamin D lowers risk of falls… What is the research flow?
Vitamin D promotes the absorption of calcium and phosphorus from the intestines and increases the reabsorption of calcium in the kidneys to regulate the appropriate concentrations of calcium and phosphorus in the blood. This plays an important role in bone health and immune system regulation. Vitamin D deficiency can lead to osteoporosis or osteomalacia, which can increase the risk of fractures or falls and the risk of autoimmune diseases.
Vitamin D is known to be deficient worldwide. There are not a few people who receive results of low vitamin D levels in the hospital and receive high-dose vitamin D therapy. However, the flow of research is different. Clinical trials published so far have shown that regular doses of vitamin D supplementation are not effective in improving bone density or preventing fractures. There is also a clinical trial report that high-dose vitamin D therapy actually increases the risk of fractures or falls. Against this backdrop, Dean Seung-kwon Myeong conducted a meta-analysis to examine the association between high-dose vitamin D therapy and fractures and falls.
High-dose vitamin D has no effect on preventing fractures and falls
The meta-analysis found no difference in the frequency of fractures or falls among those who received intermittent or episodic intramuscular and oral high-dose vitamin D therapy compared to those who used a placebo or received no treatment. On the other hand, the use of vitamin D3, which can be obtained from animals such as meat or fish, among the types of vitamin D, was found to increase the risk of dropping by 6%.
The research team cited ‘hypercalcemia’ as the reason why high-dose vitamin D therapy led to negative results. The research team explains that high-dose vitamin D administration can actually increase the risk of falls by causing bone loss and muscle weakness due to hypercalcemia and a decrease in active vitamin D concentration.
Normally no supplement needed… New recommended intake concept/definition needed
Myeong Seung-kwon, dean of the graduate school, said, “The normal level of vitamin D in the blood is 20 or 30 ng/mL for each professional society, institution, and clinic. /mL, and there is insufficient evidence that diseases such as fractures increase at this level.”
Dean Myeong said that we should be vigilant once morest indiscriminate vitamin D testing and supplementation, and advised, “Generally, vitamin D testing or supplementation is not necessary, and increase vitamin D synthesis by exposure to sunlight for at least 10 minutes a day for bone health.” . He added, “It is enough to increase intake of blue-backed fish or mushrooms containing vitamin D along with regular exercise.” In addition, since the current recommended intake of vitamin D is excessively high, it was suggested that a new concept and definition of the recommended intake is needed.
The results of this study were published online in the SCIE international journal ‘Osteoporosis International’ last April.
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