High-Dose Vitamin D Supplementation and Reduced Risk of New-Onset Atrial Fibrillation in the Elderly: A Finnish Study – Global Biotechnology

2023-07-11 08:38:03

Text/Global Biotechnology

Recently, a study by the Institute of Public Health and Clinical Nutrition at the University of Eastern Finland pointed out that high doses of vitamin D in the elderly can effectively reduce the risk of new-onset atrial fibrillation (AF). The study was published in the American Heart Journal.

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Vitamin D deficiency has been associated with increased AF incidence in previous observational studies, but few studies have investigated the effect of vitamin D supplementation on AF incidence in healthy populations.

This study aimed at a total of 2495 healthy elderly whites in the Finnish general population. It was a randomized, double-blind and placebo-controlled trial of supplementation. During the trial from September 2012 to October 2018, each subject All will take supplements continuously for five years.

The experiment first divided 2495 subjects into three groups with similar numbers, and were given (1) 1600 IU/day vitamin D (2) 3200 IU/day vitamin D (3) placebo. And at 12, 24, 36 and 60 months at the end of the experiment, questionnaires were completed at four time points to collect daily data such as body weight and medication habits, and the concentration of vitamin D (25-OH) in serum was measured.

The results showed that a total of 190 subjects were diagnosed with AF in the follow-up and collected visit records. Compared with placebo, subjects receiving 1600 IU/day of vitamin D had a 27% lower risk of developing AF; those receiving 3200 IU/day of vitamin D had a 32% lower risk of developing AF.

After deducting the 122 subjects who used antiarrhythmic drugs during the experiment, the risk of developing AF was reduced by 27% in subjects receiving 1600 IU/day vitamin D; The risk was reduced by 30% but the effect was less significant.

The researchers concluded that high-dose vitamin D supplementation in the elderly population may be helpful in preventing atrial fibrillation.

Jyrki K. Virtanen, the first author of the study, also said that the limitations of the experiment came from the inability to judge the type of AF and the subject’s AF history before the test. He also said that since the subjects of this study were all elderly whites in Finland, it cannot be directly extended to other age groups, other races or ethnicities.

Although the study concluded that high doses of vitamin D may help prevent AF, more randomized controlled trials are needed.

References:
https://www.medscape.com/viewarticle/994037
paper:https://www.sciencedirect.com/science/article/pii/S0002870323001436

The article is authorized to be reproduced from “Global Biotechnology”Finnish study: high doses of vitamin D can help reduce the risk of atrial fibrillation in the elderly

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