The doctor pointed out that some people’s immune systems are less able to resist the herpes zoster virus, so they need to be vaccinated to improve immunity; the picture shows the situation. (picture taken from shutterstock)
[Health Channel/Comprehensive Report]Ms. Cai, in her 50s, went to the doctor because of pain near her ear, accompanied by dizziness and many blisters. The doctor diagnosed herpes zoster (commonly known as skin snake) from the appearance, but Ms. Cai said that she had herpes zoster only 3 years ago. How could she get it again and it hurts more? The doctor explained that it is possible to get herpes zoster again, and because the immune system is less able to resist the herpes zoster virus, it is necessary to vaccinate to enhance immunity.
Ge Zhengxiang, the attending physician of Lin Zhengxian Dermatology Clinic, posted on his Facebook page “Dermatologist.Dr. Ge Zhengxiang“andpersonal websiteExplain that Herpes zoster (Herpes zoster), commonly known as “skin snake”, is a disease in which the virus (VZV) in the body is activated and escapes from the nerves to infect and destroy the skin. Clinically, patients will feel painful symptoms in one area (maybe tingling, throbbing, numbness, itching, heat, abnormal sensitivity), and there will be rashes one by one, often manifested as blisters.
Shingles 3 Haunting
Ge Zhengxiang said that the three most feared problems of getting herpes zoster are: pain, scars, and affecting organ function.
● Pain:Some people are in so much pain that they can’t eat or sleep, some people cry in the clinic because of the pain, and some people are so painful that they can’t sleep for several days and want to commit suicide. However, the degree of pain varies greatly from individual to individual, and some people have herpes zoster that is not very painful and has mild symptoms.
●Scars:For herpes zoster wounds, some patients will subsequently form keloids or severe pitting scars, and some patients will develop pigmentation.
●Affect organ function:For example, if it grows in the ears, it will affect hearing or balance function, if it grows in the eyes, it will damage the cornea, if it grows in the genitals, it will cause difficulty in urinating, etc.
Why do you get shingles?
Ge Zhengxiang pointed out that people who get shingles must have been infected with chickenpox virus before (chickenpox and shingles are caused by the same virus, both are VZV, the first infection is called chickenpox, and the recurrence and reactivation is called shingles). After the chickenpox is cured, the virus hides in the ganglia of the body and enters a dormant state. When the body’s immunity is weakened, or some factors wake up the dormant virus, the virus will escape from the ganglion, causing herpes zoster (such as stress, tiredness, lack of sleep, use of immunosuppressive drugs, chronic diseases, hospitalization, surgery, etc.) Confirmed Wuhan pneumonia (new coronavirus disease, COVID-19) and other conditions).
Ge Zheng explained in detail that there will be antibodies against the herpes zoster virus in the human blood, and there are also specific anti-virus T cells that will fight against the herpes zoster virus (hereinafter referred to as VZV). However, over time, the concentration of antibodies in the blood may decrease, and the memory and activity of T cells may also decline, unable to induce sufficient immunity against VZV, so you will get shingles. The way to increase antibody concentration and specific T cell activity is to take herpes zoster vaccine, which can reduce the chance of VZV activation, so you will not get shingles.
Get vaccinated against shingles
Ge Zhengxiang said that there are currently two types of shingles vaccines on the market. The first is Zostavax (zoster), which has been on the market for a long time. It is an active attenuated vaccine that contains a weakened (theoretically non-pathogenic) herpes zoster virus. The status of the infection strengthens the immune system’s familiarity with the herpes zoster virus and reduces the chance of getting sick. According to research, the protective power is about 50%. However, the attenuated vaccine has a disadvantage. People with extremely low immunity (bone marrow transplantation, organ transplantation, and moderate use of immunosuppressive drugs) are not suitable for vaccination.
Ge Zhengxiang said that the second vaccine is the new generation of Shingrix (Xinke rash), which is a recombinant protein vaccine and is not infectious to viruses. Hinkles contains the key protein of herpes zoster virus and a special adjuvant, which can very powerfully induce the body’s immune system to remember herpes zoster virus, and greatly enhance the protection against herpes zoster.
Studies have shown that Sink’s rash provides more than 90% protection, but Sink’s rash requires two injections, and the common method of administration is that there is an interval of two months between the first dose and the second dose. And because Hinkle rash is a recombinant protein, it is not infectious, so people with extremely low immunity can also be vaccinated.
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