network revealed CNN In the news, in Boston labs, blind mice regained their sight, brains developed to be smarter and younger, and healthier muscle tissue and kidneys were built. On the flip side, young mice prematurely aged, with devastating results for nearly every tissue in their bodies..
The opposite of aging itself.
Scientists can reverse aging in mice. The goal is to do the same for humans. Experiments show aging is a reversible process, said anti-aging expert David Sinclair, professor of genetics at Harvard Medical School’s Blavatnik Institute and joint director of the Paul F. Glenn Center. It can be pushed “back and forth at will”, per the biology of aging research.
Sinclair, lead author of a new paper showcasing the work of his lab and international scientists, said our bodies contain a backup of our youth that can be stimulated to regenerate..
Challenging Shared Experiments, first published in the journal Cell The scientific belief that aging is caused by genetic mutations that erode our DNA, creating an arena of damaged cellular tissue that can lead to deterioration, disease, and death..
Jae Hyun Yang, a genetics research fellow in Sinclair’s lab who co-authored the paper, said he expects the findings “will change the way we look at the aging process and the way we approach the treatment of aging-related diseases.”
The genome literally turns genes on and off. This process can be caused by pollution, environmental toxins, and human behaviors such as smoking, eating an inflammatory diet or suffering from chronic sleep deprivation. Just like a computer, Sinclair said, the cellular process gets damaged as more DNA is broken or damaged.
“The amazing finding is that there is a backup copy of the software in the body that you can reset,” Sinclair said. other.
It doesn’t matter whether the body is 50 or 75 years old, healthy or diseased, Sinclair said, once that process begins, “the body will then remember how to rejuvenate and become young once more, even if you are old or sick now, what Is this program, we don’t know yet, at this point we just know we can flip the switch”
years of research..
CNN said he began researching transformation when Sinclair was a graduate student, and was part of a team at MIT that discovered the existence of genes to control aging. This gene is present in all creatures, so there must be a way to do the same thing in people. To test this theory, he set out to try to speed up the aging of mice without causing mutations or cancer.
And he confirmed, we started experiments on this mouse when I was 39 years old, and I am now 53 years old, and we have been studying that mouse since then, and with the help of other scientists, Sinclair and his team at Harvard University were able to determine the age of brain tissue, eyes, muscles, skin and kidneys in mice .
Create the world of genetics Yuancheng Lu Sinclair Lab specialist Sinclair Lab A mixture of 3 to 4 genes, using adult human skin cells reprogrammed to behave like embryonic or pluripotent stem cells, capable of developing into any cell in the body, the cocktail was injected into damaged retinal ganglion cells in the back of the eyes of blind mice and operated remotely. The way to feed mice antibiotics, an antibiotic is just a tool, it might be any chemical really, it’s just a way to make sure all three genes are turned on, “they normally only turn on in very young fetuses, and then they turn off as we get older.”.”
The mice regained most of their sight.
Next, the team treated brain, muscle and kidney cells and restored them to much smaller levels, according to the study. Today, the Sinclair lab team is trying to Sinclair Finding a way to evenly deliver the gene switch to each cell, thus rejuvenating the entire mouse at once.
He said, billions of dollars are being poured into anti-aging, funding all kinds of methods to turn back the clock, adding that his team has reset cells in mice several times, showing that aging can be reversed more than once, and he is currently testing genetic reset in mice. primates, but it may be decades before any human anti-aging clinical trials begin, are analyzed, and, if safe and successful, expanded to the size required for federal approval..
Sinclair revealed that just as harmful agents can disrupt the epigenome, healthy behaviors can fix it. His top tips are to focus on plants for food, eat less, get enough sleep, and exercise 3 times a week to maintain muscle mass. your muscles.