2023-08-28 09:21:53
The results are significant: at the same number of calories, the mice with a fatty diet gained more weight when they also consumed gluten (8.8% of additional fat mass), which suggests that gluten accentuates the effects harmful fats and is a risk factor for obesity.
On the same subject
Celiac disease: 5 things to know regarding gluten intolerance
Celiac disease is a chronic autoimmune disease that affects 1% of the population. “In some people, the ingestion of a protein present in flour (wheat, barley, rye) – gluten – triggers an exaggerated reaction of the immune system, resulting in inflammation leading to the destruction of the villi of the intestinal mucosa” , notes the French National Society of Gastroenterology (SNFGE). Celiac disease is therefore not a food allergy but an autoimmune disease linked to a genetic predisposition. According to the SNFGE, only 10 to 20% of cases are diagnosed.
Lesions likely to disrupt the hypothalamus?
More worryingly, even with a healthy, low-fat diet, mice that ate gluten saw their levels of astrocytes and microglia – immune cells – increase significantly, a sign of general inflammation that might disrupt the hypothalamus, the area of the brain that controls hormonal secretions and the activity of the vegetative nervous system.
“If gluten leads to hypothalamic inflammation and therefore brain damage, it can have long-term adverse effects, such as increased body weight and impaired blood sugar regulation”, and therefore increase the risk of diabetes , but also senile dementia, alert the researchers, who must now carry out new research to find out if this phenomenon observed in mice can be transposed to humans.
Gluten is ubiquitous in the world diet. Wheat, rye, barley, spelled, oats… hard to avoid in our diets, especially in the West. Over time, the food industry has also favored varieties of cereals that are increasingly rich in gluten, whose elastic properties facilitate soft, tender or airy preparations.
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