Today (8 May 65) the page of the Medical Genome Center, Ramathibodi Hospital, Mahidol University. Reveal the subspecies of the omikron to watch out for. One passage describes a mutation in the coronavirus 2019 genome, where the spike gene at the location “452” may have been a major contributor. “Omicron subspecies BA.4, BA.5, and BA.2.12.1” have the ability to spread faster. It also has the ability to connect cell walls (lungs) from multiple cells into a single cell. It can cause inflammation of the lung tissue, as is the case with past outbreaks of “delta” strains.
The entire genome of the 2019 novel coronavirus found a change in the thorn region at “452” from the amino acid “leucine (L)” to “arginine (R)” or “A”. Lutamine (Q)” gives the spines properties that can connect neighboring cell walls. fused into a single cell As a result, the virus can rapidly spread cell-to-cell without leaving the cell at risk of being caught and destroyed by antibodies created in the body of a previously infected person naturally and by vaccination. The fused lung cells infected with the 2019 coronavirus are fused into one large cell with multiple nuclei. The DNA inside these cells is broken and broken. This makes the immune system of the infected person look foreign and destroys those multinucleated cells. Inflammation progresses, leading to pneumonia, which can lead to the death of the infected person.
The Genome Center also said the “delta” strain had a spiny “R452” mutation, causing severe infections. As a result of pneumonia from the fusion of several infected cells into one cell. In contrast to the original omikron strains (B.1.1529) such as BA.1, BA.1.1 and BA.2, there were no mutations. The amino acid remains “L452”, consistent with the clinical manifestations of the original, mild omikron strain. One reason may be that it does not occur in infected lung cells.
But worryingly is that both the “BA.4” and “BA.5” viruses, which the WHO announced as an outbreak in South Africa, have been mutated in R452. It has a mutation in “Q452”, back to the “delta” strain, which is capable of causing multiple infected cells to fuse into the same cell.
Consequently, it is likely that the substituents of omikron BA.4, BA.5, BA.2.12.1 may be more severely infected than the original omikron, which the WHO and scientists around the world are monitoring. Clinical manifestations of BA.4, BA.5 and BA.2.12.1 infections in South Africa and the United States in 2-4 weeks. The latest update shows that the number of patients who need to be hospitalized in 2 countries has started to increase. But the death rate remains the same.