2023-04-28 12:45:14
Dr. Theerawat warns once morest taking too much fish oil. risk of irregular heartbeat
On April 28, Dr. Theerawat Hemachutha, Head of the Center for Emerging Disease Health Sciences Faculty of Medicine Chulalongkorn Hospital, Thai Red Cross Society, posted a message via Facebook stating that fish oil is good … but accompanied by a pulsating heartbeat. As the doctor has told me regarding the goodness of fish oil, which is the key. known as the EPA and the DHA, where both of these It’s been proven to help prevent Alzheimer’s dementia, but when symptoms show, it doesn’t even work with a tiny fish oil called plasmalogen. Which is actually fish oil that has been passed through the liver and converted to the tiny body. where people with dementia already
The process that makes fish oil go through various developments until it reaches the intracerebral blood vessels into the brain. And getting into different cells will be impossible.
In addition, fish oil containing these two components. When used in high doses of 3 to 4 grams per day, it can help prevent clogged arteries. Including the cerebral vessels as well And later reports found that help alleviate Relieve patients with various levels of heart attack.
Thus, the fish oil-related business, also known as omega-3 fatty acids, exploded. In 2019, the global market reached $4.1 trillion and is estimated to be within 2019. 2025 The market will double as the good evidence gradually comes out.
but anyway It is very necessary to have a risk assessment. to the side effects that will occur This is because the size used is much higher than what is commonly used as a dietary supplement, which contains much lower amounts of EPA DHA.
Reported in the March 16, 2021, issue of the Journal of the American Medical Association (JAMA), the VITAL Rhythm study analyzed the potential effects of high fish oil consumption. with an abnormal heartbeat that Thai people call heart palpitations (AF Atrial fibrilla- tion) and causes the heart to squeeze The intensity of each squeeze is not equal causing thick blood to remain in the heart cavity. and eventually slipped away from the heart to clog the blood vessels
Especially the blood vessels in the brain as a major artery. and cause cerebral necrosis resulting in hemiplegia and if it’s the big brain on the left It will make listening to understand the language. and speech wasted and if it goes to other parts of the brain For example, the occipital part of the brain or the brainstem will have symptoms according to the function of that part of the brain. And can still be able to clog various blood vessels throughout the body, both limbs and blood vessels that feed the intestines in the stomach
For people with such arrhythmias, they need to be on medication to prevent blood clots.
As an editorial in this journal concludes, over the past two years, four large studies have been conducted reporting on the risk of AF in the STRENGTH trial, involving 13,078 participants. are randomly at risk for coronary heart disease and were divided into groups that received 4 grams of fish oil per day or corn oil. After a median follow-up of 42 months, the risk of AF in the fish oil group increased 2.2% vs 1.3% hazard ratio, 1.69; 95% CI, 1.29-2.21; P<.001.
In the REDUCE–IT study, 8179 participants received either EPA or mineral oil and were followed for 4.9 years, the fish oil group had a 25% reduction in the relative risk of coronary heart disease. There was an increased risk of AF (5.3% vs 3.9%; P = .003). and recently had a coronary artery thromboembolism receiving 1.8 g/day of moderate-dose fish oil, both EPA and DHA, or corn oil. After two years of follow-up, there was no difference in the risk of cardiovascular disease, but 7.2% of the fish oil group developed AF compared to 4.0% of the corn oil group (hazard ratio, 1.84; 95). %CI, 0.98–3.45 ; P=.06).
And in a recent VITAL Rhythm study published in this journal. A total of 12,542 participants were given 840 mg/day of fish oil, a combination of EPA and DHA, compared to a placebo. After a 5.3-year follow-up, the incidence of AF in the fish oil group was 7.2 per 1000 person-years (person-years) compared to 6.6 per 1000 in the placebo group (hazard ratio, 1.09; 95%CI, 0.96 to 1.24). ; P=.19)
When collecting all the evidence for the four reports of the study project, may point to one level Although this is not definitive proof that The amount or dose of fish oil seems to have contributed to the risk of AF, with the high dose of 4 grams per day nearly doubling the risk and at the moderate dose of 1.8 grams per day appearing. There was an increased risk, although not statistically significant (hazard ratio, 1.84).
And at the usual dose of 840 milligrams per day, there was no apparent risk.
Therefore, the consumption of fish oil to prevent Alleviate or slow down diseases that require high doses. may have to weigh with the potential risk of atrial fibrillation AF, which occurs even following discontinuation of fish oil It does not disappear and will require a special type of anticoagulant medication. that are not antiplatelet drugs, aspirin or drugs in the same group But it has to use a specific group, such as warfarin.
Where there must be a blood test to adjust the dose to an appropriate level, not too much, it will bleed easily. or less, it doesn’t work
Although the drug is easier to use without blood work (NOAC), but the price is quite high. And if it’s over-acting, it’s necessary to use an antidote. Which is quite difficult and all these drugs, if surgery is required, it is necessary to stop the drug first. Which is at risk of blood clots and while using the drug, because the blood is easier than normal, if an accident will be more intense, the blood stopping slowly, and emergency surgery must be prepared for more steps.
This is an example of a drug where the benefits, side effects and potential harms are known, and the dosage is required. With concern for everyone’s health.
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