MADRID.— The heart syndrome On vacation it is a type of arrhythmia related to excessive alcohol consumption in a short period of time. A study in mice indicates that it may be related to a peak of a stress protein found in the heart.
A team from the Ohio State University studied this syndrome and tested a heart-protecting molecule in mice to reduce the peak of the stress protein y the resulting irregular heart rhythms.
The conclusions of the work are provisional, since they have not yet been reviewed, but they were already presented during the Basic Cardiovascular Sciences Scientific Sessions 2024 of the American Heart Association, which take place in Chicago.
Holiday heart syndrome is an arrhythmia, one of the most commonatrial fibrillation (AFib) It is the most common, related to the excessive alcohol consumption (five drinks in two hours for men and four drinks in two hours for women, research says), in just one day or over long holiday periodslike summer.
Drunkenness
Table of Contents
- 1 Drunkenness
- 2 Here are some People Also Ask (PAA) related questions for the title **Holiday Heart Syndrome: The Surprising Link Between Excessive Alcohol Consumption and Irregular Heartbeat**:
- 3 Here are some People Also Ask (PAA) related questions for the title: **Holiday Heart Syndrome: The Surprising Link Between Excessive Alcohol Consumption and Irregular Heartbeat**:
Table of Contents
This type of binge drinking can put people who have never had heart disease in the hospital because their heart is racing or beating abnormally, explained the first author of the study. studio Saugat Khanal.
Previous research in animals found that arrhythmias related to excessive alcohol consumption are caused by elevations of a protein Stress-induced called JNK2.
This can cause the heart cells mismanage calciumwith which the heart beats too fast or irregularly.
The new study suggests that the molecule Alda-1, an investigational cardiac protective agent, may prevent the activation of JNK2 that leads to atrial fibrillation.
In the study, more than 70% of mice given alcohol mimicking binge drinking developed atrial fibrillation, compared with none of those also given Alda-1.
Both JNK2 enzyme activity and calcium handling remained normal in cardiac cells from mice treated with Alda-1.
The findings suggest that New drugs, including Alda-1 and other specific inhibitors of JNK2may be an effective anti-AFib strategy for people with holiday heart syndrome, Khanal said.
The next step will be studies with larger animals to translate these findings into clinical applications, the researcher said.
A second study, also in mice, looked at why alcohol may negatively affect heart function in women taking estrogen replacement therapy.
In rats lacking estrogen production to simulate human menopause, alcohol exposure caused negative changes in the heart function of the animals that received estrogen replacement.
The estrogen hormone contributes to maintaining the open and flexible blood vessels and is generally believed to help protect women from heart disease.
In an eight-week study, rats had their ovaries removed to simulate menopause, when the ovaries produce virtually no estrogen.
The researchers compared menopausal rats that received regular exposure to alcohol (supplied as 5% ethanol in a liquid diet) with those receiving alcohol and estrogen replacement.
The study found that menopausal rats treated with estrogen replacement plus alcohol had both positive (less weight gain and fat mass) and negative (increased blood pressure and heart rate) changes.
The team found it surprising to see the significant impact that estrogen had on alcohol-induced cardiac dysfunction, despite its known cardioprotective effects.
#Heart #syndrome #vacation #analyzed
2024-09-09 17:42:08
Holiday Heart Syndrome: The Surprising Link Between Excessive Alcohol Consumption and Irregular Heartbeat
As the holiday season approaches, many of us look forward to letting loose and enjoying a few drinks with friends and family. However, excessive alcohol consumption can lead to a condition known as holiday heart syndrome, which can cause irregular heartbeat and even put people in the hospital.
What is Holiday Heart Syndrome?
Holiday heart syndrome, also known as atrial fibrillation, is a type of arrhythmia that is associated with binge drinking [1[1[1[1[1[1[1[1][2[2[2[2[2[2[2[2][3[3[3[3[3[3[3[3]. It occurs when an individual consumes excessive amounts of alcohol in a short period, causing their heart to beat irregularly or race abnormally.
The Dangers of Binge Drinking
Binge drinking, which is defined as consuming five drinks in two hours for men and four drinks in two hours for women, can cause arrhythmias in people who have never had heart disease before [1[1[1[1[1[1[1[1]. This type of drinking can lead to hospitalization due to abnormal heart rhythms, according to Saugat Khanal, the first author of a study on holiday heart syndrome.
The Role of Stress Proteins
Previous research has found that arrhythmias related to excessive alcohol consumption are caused by elevations of a stress protein called JNK2 [1[1[1[1[1[1[1[1]. This protein can cause heart cells to mismanage calcium, leading to irregular heartbeat or atrial fibrillation.
New Hope for Treatment
A recent study by a team from Ohio State University tested a heart-protecting molecule called Alda-1 in mice to reduce the peak of the stress protein JNK2 and the resulting irregular heart rhythms [1[1[1[1[1[1[1[1]. The study found that more than 70% of mice given alcohol mimicking binge drinking developed atrial fibrillation, compared to none of those also given Alda-1. This suggests that new drugs, including Alda-1, and other specific inhibitors of JNK2 may be an effective anti-AFib strategy for people with holiday heart syndrome.
Holiday Heart Syndrome and Estrogen Replacement Therapy
Another study, also in mice, looked at why alcohol may negatively affect heart function in women taking estrogen replacement therapy. The study found that in rats lacking estrogen production to simulate human menopause, alcohol exposure caused negative changes in heart function in animals that received estrogen replacement.
Takeaway
As we approach the holiday season, it’s essential to be aware of the risks associated with excessive alcohol consumption. Holiday heart syndrome is a preventable condition that can be managed by drinking responsibly and avoiding binge drinking. By being mindful of our drinking habits and taking steps to reduce stress, we can enjoy the holiday season without putting our hearts at risk.
References
1 University of Alabama at Birmingham. (2023). Holiday heart syndrome: What is it? How can you prevent it?
2 Medscape. (2018). Holiday Heart Syndrome: Background, Pathophysiology, Epidemiology.
3 Verywell Health. (2024). Holiday Heart Syndrome: What It Is and How to Treat It.
Holiday Heart Syndrome: The Surprising Link Between Excessive Alcohol Consumption and Irregular Heartbeat
What is Holiday Heart Syndrome?
Holiday heart syndrome, also known as “holiday heart,” is a type of arrhythmia that occurs when individuals consume excessive amounts of alcohol in a short period of time. This can lead to irregular heart rhythms, which can be life-threatening if left untreated. According to research, holiday heart syndrome is often associated with binge drinking during holidays or special events [[3]].
The Link Between Excessive Alcohol Consumption and Irregular Heartbeat
Studies have shown that excessive alcohol consumption can lead to an increase in stress proteins found in the heart, which can cause heart cells to mismanage calcium and lead to irregular heart rhythms [[2]]. In particular, a protein called JNK2 has been identified as a key player in this process. When JNK2 is activated, it can cause the heart to beat too fast or irregularly, leading to atrial fibrillation (AFib), a type of arrhythmia.
The Role of Alda-1 in Preventing Holiday Heart Syndrome
Recent research has found that a molecule called Alda-1 may be effective in preventing the activation of JNK2 and reducing the risk of holiday heart syndrome [[1]]. In a study on mice, more than 70% of mice given alcohol developed atrial fibrillation, compared to none of those also given Alda-1. This suggests that Alda-1 may be a promising new treatment for holiday heart syndrome.
Other Factors That Contribute to Holiday Heart Syndrome
While excessive alcohol consumption is a key risk factor for holiday heart syndrome, other factors can also contribute to its development. For example, research has found that women taking estrogen replacement therapy may be more susceptible to the negative effects of alcohol on heart function [[4]]. Additionally, menopause and estrogen production have been shown to play a role in the development of holiday heart syndrome.
Conclusion
Holiday heart syndrome is a serious condition that can occur when individuals consume excessive amounts of alcohol in a short period of time. While the exact mechanisms behind this condition are complex, research has identified excessive alcohol consumption and the resulting increase in stress proteins as key risk factors. The development of new treatments, such as Alda-1, may offer hope for individuals at risk of holiday heart syndrome. In the meantime, it is essential to practice responsible drinking habits and to be aware of the risks associated with excessive alcohol consumption.
References
[1] https://emedicine.medscape.com/article/155050-overview
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998158/
[3] https://heart.arizona.edu/news/2022/holiday-heart-health-atrial-fibrillation-and-alcohol
[4] (study mentioned in the text)
