2024-06-25 14:42:25
[메디컬투데이=최재백 기자] Weight problems induced by a high-fat weight-reduction plan has been proven to exacerbate nervousness by disrupting the intestine microbiome and gut-brain signaling.
The findings, revealed in BMC Organic Analysis, recommend that weight problems attributable to a high-fat weight-reduction plan can disrupt the intestine microbiome and gut-brain signaling, thereby exacerbating nervousness.
A group of researchers from the College of Colorado Boulder studied the consequences of a nine-week high-fat weight-reduction plan in mice to uncover the complicated relationship between high-fat diets, nervousness, weight problems, and the intestine microbiome.
The analysis group divided the mice into two teams: one group (12 mice) obtained a management weight-reduction plan wherein fats content material accounted for 11% of each day energy consumed; the opposite group (12 mice) obtained a high-fat weight-reduction plan wherein fats content material accounted for 45% of each day calorie consumption, which I used to be advised to do.
They underwent weekly stool checks to research modifications of their intestine microbiome and carried out behavioral checks on the finish of the examine. As well as, modifications in diet-related physique composition values, akin to closing weight, diploma of weight achieve, and physique fats, have been recorded.
The outcomes confirmed that mice fed a high-fat weight-reduction plan not solely gained weight and physique fats, but in addition had a big lower in intestine microbiome variety. Particularly, the ratio of Firmicutes to Bacteroidetes was discovered to be excessive, an indicator of intestine microbiome dysbiosis, which regularly accompanies weight problems and a Western weight-reduction plan.
The group added that the high-fat weight-reduction plan group confirmed elevated expression of genes associated to serotonin manufacturing and signaling within the dorsal raphe nucleus within the brainstem, which is related to nervousness and stress.
They clarify that whereas serotonin is mostly regarded as a cheerful chemical, some serotonin can quickly induce behavioral responses of concern or nervousness.
They imagine {that a} high-fat weight-reduction plan alters the composition of the intestine microbiome, resulting in elevated physique fats and weight, in addition to anxiety-related modifications within the mind’s serotonin system. In different phrases, weight problems induced by a high-fat weight-reduction plan could disrupt signaling alongside the microbiome-gut-serotonin mind axis, resulting in a rise in anxiety-related behaviors.
Specialists say a high-fat weight-reduction plan tends to scale back the general variety of the intestine microbiome, and a much less complicated microbial group is tougher to keep up a balanced setting.
Subsequent, they discovered that about 95% of serotonin, a neurotransmitter important for temper regulation, is discovered within the gastrointestinal tract, and since serotonin is primarily produced within the intestine, the intestine microbiome may modulate serotonin ranges and affect general psychological well being, akin to temper and emotion. “That’s loopy,” he added.
For instance, if intestinal permeability and systemic irritation are elevated and serotonin signaling is altered as a result of an imbalance within the intestine microbiome, this might result in or worsen psychological well being circumstances akin to nervousness, post-traumatic stress dysfunction, and despair.
Specialists say that regardless of organic variations between rats and people, the totally different species share frequent physiological and biochemical mechanisms, so the essential rules of the microbiome-gut-brain axis found in rats will be successfully utilized to human well being evaluation.
They hope that additional analysis into the microbiome-gut-serotonin-brain axis may result in future therapies focusing on the intestine microbiome to modulate mind operate and enhance psychological well being.
In the meantime, rising your consumption of wholesome fat and lowering your consumption of unhealthy fat can assist enhance general psychological well being by aiding gut-brain signaling and decreasing irritation.
Oily fish wealthy in omega-3, chia seeds, walnuts, flax seeds, fermented meals, prebiotic meals akin to garlic, onions, asparagus, bananas, oats and berries can successfully improve the variety of intestinal microorganisms and promote intestinal well being.
In the present day Medical Video Enhancing Workforce (press@mdtoday.co.kr)
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