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[이데일리 송영두 기자] A study result showed that the use of a medium (cell feed) for cell culture, which is essential for cell therapy products, affects safety.
Excel Therapeutics, a leading media company in Korea, published a paper comparing the characteristics of cells cultured in SFD medium (serum-free medium) and FBS medium (fetal bovine serum) developed in-house for mesenchymal stem cell culture in the SCI-level international scientific journal Nature ( Nature) announced on the 13th that it had been approved for publication in ‘Scientific Reports’.
The key content of this paper is a comparison of cells cultured using a serum-free medium (CellCorTM SFD MSC) developed by Excel Therapeutics and FBS medium. As a result of comparing culture performance, cellular senescence, immunogenicity, and genetic stability, it was found that the expression of genes and proteins in cells may vary depending on the medium used for culture.
The company explained that the results of this thesis will give considerable implications to the ‘stability and safety’ issue of media containing animal-derived substances, which has been continuously raised in academia and industry.
Lee Joo-yeon, director of Excel Therapeutics Research Center, who led the thesis writing, emphasized, “In order for the advanced regenerative medicine and high-tech biopharmaceutical industry to take a step forward, it is essential to secure a medium that can guarantee ‘safety’ above all else.” Ticks will continue to work hard to develop a safe medium.”
On the other hand, Excel Therapeutics plans to publish a thesis that compares and analyzes the chemical composition serum-free medium (CD), which is an advanced medium from the serum-free medium used in this paper, and the existing medium.
