Endocrine disrupting chemicals mimic, block, or interfere with hormones in the body’s endocrine system.
There was a worrying trend towards earlier puberty in girls, suggesting the influence of chemicals in our environment.
Early puberty is associated with an increased risk of psychosocial problems, obesity, diabetes, cardiovascular disease, and breast cancer.
“We conducted a comprehensive screening of 10,000 environmental compounds with extensive follow-up studies using human brain cells that control the reproductive axis, and our team identified several that may contribute to early puberty in girls,” said study author Dr. Natalie Shaw, of the National Institute of Environmental Health Sciences at the National Institutes of Health (NIH) in Durham, North Carolina.
These substances include musk extract, a fragrance used in some detergents, perfumes, and personal care products, and a group of medications called cholinergic agonists.
“More research is needed to confirm our findings,” Shaw noted. “But the ability of these compounds to stimulate key receptors in the hypothalamus — the gonadotropin-releasing hormone receptor (GnRHR) and the kisspeptin receptor (KISS1R) — raises the possibility that exposure to them could lead to premature activation of the reproductive axis in children.”
According to the research team, musk ambrette extract is of concern because it can be found in personal care products, and some studies in mice have suggested that it can cross the blood-brain barrier. Children are unlikely to encounter cholinergic agonists in their daily lives.
As part of the study, the research team screened the Tox21 library of 10,000 compounds from licensed drugs, environmental chemicals and dietary supplements against a human cell line that overexpresses either GnRHR or KISS1R. They performed follow-up analysis using human hypothalamic neurons and zebrafish, and found that geranium increased the number of GnRH neurons and GnRH expression.
“The use of human hypothalamic neurons and zebrafish provides an efficient model for identifying environmental substances that stimulate KISS1R and GnRHR,” said co-author Menghang Xia, Ph.D., of the National Center for Advancing Translational Sciences (NCATS) in Bethesda, Maryland, part of the National Institutes of Health.
Source: Medical Express
#Chemicals #push #girls #early #puberty
2024-09-11 12:21:13
Endocrine disruptors list
Table of Contents
The Alarming Impact of Endocrine Disrupting Chemicals on Puberty and Reproductive Health
Endocrine disrupting chemicals (EDCs) are substances that mimic, block, or interfere with hormones in the body’s endocrine system. These chemicals are found in our environment and have been linked to a worrying trend towards earlier puberty in girls. Early puberty, in turn, is associated with an increased risk of psychosocial problems, obesity, diabetes, cardiovascular disease, and breast cancer.
Research has shown that exposure to EDCs can affect not only energy balance and adiposity but also puberty and reproduction [1[1[1[1[1[1[1[1]. In particular, EDCs have been suggested as affecting the age of pubertal onset, especially in girls [2[2[2[2[2[2[2[2].
A recent study conducted by the National Institute of Environmental Health Sciences at the National Institutes of Health (NIH) in Durham, North Carolina, identified several environmental compounds that may contribute to early puberty in girls. These substances include musk extract, a fragrance used in some detergents, perfumes, and personal care products, and a group of medications called cholinergic agonists. The study found that these compounds can stimulate key receptors in the hypothalamus, raising the possibility that exposure to them could lead to premature activation of the reproductive axis in children.
Musk ambrette extract is of particular concern because it can be found in personal care products and has been shown to cross the blood-brain barrier in some studies in mice. While children are unlikely to encounter cholinergic agonists in their daily lives, the study highlights the need for further research to confirm these findings and understand the potential risks associated with EDCs.
The impact of EDCs on puberty and reproductive health is a growing concern, and more research is needed to fully understand the effects of these chemicals on human health. As noted by Dr. Natalie Shaw, study author, “More research is needed to confirm our findings… But the ability of these compounds to stimulate key receptors in the hypothalamus raises the possibility that exposure to them could lead to premature activation of the reproductive axis in children.”
In recent years, there has been a growing body of research on the role of EDCs during puberty [3[3[3[3[3[3[3[3]. This research has highlighted the need for a better understanding of the effects of EDCs on human health and the importance of reducing exposure to these chemicals in our environment.
the impact of endocrine disrupting chemicals on puberty and reproductive health is a pressing concern that requires further research and attention. By understanding the effects of EDCs on human health, we can take steps to reduce exposure to these chemicals and protect the health and well-being of future generations.
Endocrine disruptors list
The Alarming Impact of Endocrine Disrupting Chemicals on Puberty and Reproductive Health
Endocrine disrupting chemicals (EDCs) are substances that mimic, block, or interfere with hormones in the body’s endocrine system [1[1]. These chemicals are found in our environment and have been linked to a worrying trend towards earlier puberty in girls. Early puberty, in turn, is associated with an increased risk of psychosocial problems, obesity, diabetes, cardiovascular disease, and breast cancer.
Research has shown that exposure to EDCs can affect not only energy balance and adiposity but also puberty and reproduction [2[2]. In particular, EDCs have been suggested as affecting the age of pubertal onset, especially in girls.
A recent study conducted by the National Institute of Environmental Health Sciences at the National Institutes of Health (NIH) in Durham, North Carolina, identified several environmental compounds that may contribute to early puberty in girls. These substances include musk extract, a fragrance used in some detergents, perfumes, and personal care products, and a group of medications called cholinergic agonists. The study found that these compounds can stimulate key receptors in the hypothalamus, raising the possibility that exposure to them could lead to premature activation of the reproductive axis in children.
Musk ambrette extract is of particular concern because it can be found in personal care products and has been shown to cross the blood-brain barrier in some studies in mice. While children are unlikely to encounter cholinergic agonists in their daily lives, the study highlights the need for further research to confirm these findings and understand the potential risks associated with EDCs.
The impact of EDCs on puberty and reproductive health is a growing concern, and more research is needed to fully understand the effects of these chemicals on human health. As noted by Dr. Natalie Shaw, study author, “More research is needed to confirm our findings… But the ability of these compounds to stimulate key receptors in the hypothalamus raises the possibility that exposure to them could lead to premature activation of the reproductive axis in children.”
In recent years, there has been a growing body of research on the role of EDCs during puberty [3[3]. This research has highlighted the need for a better understanding of the effects of EDCs on human
