If talking regarding Andrographolide Nano Emulsion, many people may not know what this substance is useful for until a team of researchers from Khon Kaen University And the research team from Miss Lily Co., Ltd. picked up this substance to study and found that it can help increase the efficiency of the important active ingredient in Andrographis paniculata, used for anti-virus. for the first time in the world Ready to accelerate the development of a product that will be released soon.
The origin of the research from the shelf to the mall Enhance the efficiency of Andrographis paniculata, create drug security for the country
For the source of research from the shelf to the mall By studying the important substances in Andrographis paniculata that can prevent and stop covids, it is ‘Andrographolide’ (Andrographolide) and find a way to increase efficiency of this substance
by Assoc.Prof.Dr. Chanchai Phanthongwiriyakul, MD. Rector of Khon Kaen University Provide more information on the origin of the invention of this research.
“The spread of the coronavirus causing the name of the herb Andrographis paniculata to become the hope of relieving the patient’s condition. because it has protective properties treat cold symptoms and inhibit the proliferation of the virus.”
“The important substance in Fah Talai Thief that can prevent and stop covids is ‘Andrographolide’ (Andrographolide), which today. This substance has received international attention. It has been developed even more with medical technology. And there is a lot of research on medical information abroad. Khon Kaen University The research department and graduate studies have been conducting research studies on such substances all along. Until recently, successfully inventing a method for using andrographolide to benefit the body effectively. in the form of a nanoemulsion (nano-emulsion)”
side Prof. Dr. Monchai Duangchinda Vice President for Research and Graduate Studies Khon Kaen University revealed the findings from this research further that
“Andrographolide, a substance in the Diterpene Lactone group, is the active ingredient found in the herb Andrographis paniculata. (Andrographis paniculate) with academic reports both in Thailand and abroad that have antipyretic, anti-inflammatory and antiviral It is a bitter substance.”
“Currently, the herb Andrographis paniculata is used from leaves. or other parts or crude extracts in the form of pills, tablets and capsules widely in Thailand However, the use in capsule form There will be approximately 1.38-3.21% of andrographolides, depending on the planting site.”
and because it is insoluble in water As a result, andrographolide is absorbed and utilized in the body only 2.67%, thus requiring intake of 4 capsules at a time and continuously 4 times a day, totaling 12 capsules/day or obtaining the amount of powder. Dosage 6,000 mg/day which is equivalent to 60 mg/day andrographolide.”
“The team has researched and developed pure andrographolide products (>98%) with nanoemulsion technology. which increases the efficiency of absorption by many times It uses a small amount but has a high level of efficiency. Reduce the risk of taking herbs in the normal form in excess (over dose) is the use of knowledge and technology from research to take advantage and extend to products for health care of Thai people in the situation of COVID-19. truly.”
hand in hand with the business sector Develop research into practical applications to treat covid patients
As mentioned from the beginning that this research is a collaboration between the business sectors, Miss Lily Company Limited has a research team to study and research to develop both cosmetic and medicinal products continuously. Until this time, we have cooperated with Khon Kaen University to create commercial research to help take care of Thai people during the Covid-19 epidemic crisis Still not resolved
Dr. Nopparat Inwiset Head of the research team, Miss Lily Co., Ltd. said
“Nanoemulsion technology has been used in many products for a long time. whether it is a product in the cosmetic group and medicine However, andrographolide has not been developed in this form. Most of the research is on the medicinal benefits of andrographolide in powder form.”
“Even nanoemulsification in the laboratory itself faces many problems, such as uniformity of particles smaller than 100 nm. In addition, the stability of the solution is difficult. In the experiment, the appropriate type of substance and quantity must be found. and the pH must be adjusted so that the substance does not oxidation. And it’s not so acidic that it’s dangerous. Including must be flavored to reduce the bitterness of andrographolide. and has a flavor that is suitable for all ages.”
“Even more difficult is converting the manufacturing process from the laboratory to the manufacturing plant. Many obstacles were encountered due to the state-of-the-art laboratory equipment. and has high flexibility in working Whether it is a high speed homogenizer or an ultrasonic machine that can adjust the rotation speed up to 10,000 rpm, which makes the laboratory production of good and consistent quality.”
“While the machinery in most factories in Thailand Unable to produce products according to the specified standards, Miss Lily has to send a team of engineers. come to receive the transfer of the production process from the laboratory to the factory By entering the factory to modify the machine to produce products according to the specified standards. This is the hardest part of doing research into the market. because there is a lack of connection of research from the laboratory to the production process in the factory.”
following this Khon Kaen University will continue cooperation with Miss Lily Company Limited, Thailand’s first floral e-commerce company. to develop health products into the market by focusing on creating new experiences that can meet health needs for consumers The products that will be developed will be in line with the current consumer demand direction. which the university There will be a press release on the next occasion.
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