Diabetic men are more susceptible to erectile dysfunction, as their bodies are unable to effectively control blood sugar levels, which leads to high levels of sugar that damage the blood vessels and nerves responsible for erection.
Viagra medications (known as PDE5 inhibitors) treat erectile dysfunction by increasing levels of nitric oxide, which dilates blood vessels to improve blood flow. The effect of these medications lasts for up to 4 hours. Although it is successful in about 70% of cases, it is not suitable for some patients, such as those who take nitrate medications to treat angina, those with liver problems, or those who have recently suffered a stroke.
In the new trial, 32 men who suffered from severe erectile dysfunction or whose condition did not respond to Viagra medications underwent a treatment that included the use of a single injection of “botulinum toxin” (the active ingredient in Botox) to block the nerve signals that make muscles contract, in addition to a daily dose. of tadalafil (5 mg) for 3 months.
Previous research indicates that this toxin may help treat erectile dysfunction by relaxing the muscles surrounding the blood vessels supplying the penis, which improves blood flow. It also disrupts the secretion of norepinephrine, a chemical transmitter that reduces blood flow.
This trial comes after a previous study conducted on 216 men, most of whom did not respond to medications similar to Viagra. At the beginning of that study, participants were given two injections of Botox, after applying an anesthetic cream.
After the first injection, 85% of men with mild erectile dysfunction showed significant improvement, as did 79% of those with moderate cases and 64% of severe cases.
Over 6 years, more injections were performed as needed, as the response increased with repeated injections, although the reason is not clear. By the end of the trial, the results showed a 50% improvement in cases of mild and moderate erectile dysfunction, and a nearly 3-fold improvement in severe cases, according to results published by researchers at Poincaré University Hospital in France, in the journal Toxins.
The results of the new experiment, which is being conducted at Aswan University in Egypt, are expected to appear during the next year.
Commenting on the study, Professor Raj Persad, a consultant urologist at Bristol Urology Associates, said: “Using Botox appears to be an attractive option. “If the trial proves effective in daily clinical practice, this approach may provide more flexibility for treating erectile dysfunction.”
Source: Daily Mail
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