discovery of a link with diabetes

2023-10-24 06:00:04

The team of Dr. Jennifer Estall, researcher at the Montreal Clinical Research Institute (IRCM) and professor at the University of Montreal, recently published a study that provides new knowledge on two major metabolic diseases: diabetes ( Diabetes presents several forms, which all have in common abundant urine…) and fatty liver, commonly called disease (The disease is an alteration of the functions or health of a living organism, animal…) of the foie gras.
The study revealed the abnormally high presence of proteins called sIL-6R and sgp130 in the blood of patients with fatty liver disease. Credit: Getty

Published in the scientific journal Diabetes, the study highlights the way in which these diseases influence each other and identifies new biomarkers and new targets. potential therapeutics.

Abnormally high presence of certain proteins

Led by Dr. Aysim Gunes, first author of the publication and research associate in Dr. Estall’s laboratory, the study revealed the abnormally high presence of proteins called sIL-6R and sgp130 in the blood of patients with fatty liver disease, an even more marked presence among people living with diabetes. The team was able to establish that high levels of sugar and lipids, as in the case of diabetes, encourage different types of liver cells to produce these proteins, which participate in control (The word control can have several meanings. It can be used as a synonym for examination,…) of inflammation (Inflammation is a stereotyped immune defense reaction of…).

Above all, this work demonstrated that the concentration of sgp130 in the blood is a very good indicator of liver damage in both men and women, which suggests that this protein might also be a good circulating biomarker of liver disease. Current biomarkers for steatotic liver disease only detect advanced stages of the disease and many of them function differently in men. and in women.

“We have long sought to understand how fatty liver disease is linked to type 2 diabetes. Our study may explain why fatty liver disease is more common in diabetics and why diabetes appears to worsen this metabolic liver disease. It also offers new insight. promising means of detecting liver damage in patients suffering from a metabolic disease”, mentioned Dr. Estall, director of the Research Unit (Scientific research refers primarily to all the actions undertaken with a view to… ) on the molecular mechanisms of diabetes from the IRCM.

“Our discovery of an effective new biomarker of liver damage in early stages of fatty liver disease might pave the way for new non-invasive tests to diagnose the disease earlier,” said Dr. Gunes.

About fatty liver disease

Fatty liver disease is a metabolic disease that affects 25% of the general population by creating an accumulation of fat and scar tissue in the liver. Although it causes few symptoms, this disease is known to cause significant damage to the liver over time, which ultimately impacts metabolism. …) medications and detoxification of toxins while increasing the risk of cancer. In the absence of sensitive means of measuring damage to the liver in its early stages, the disease is difficult to diagnose at an early stage, when it is still reversible by diet (For cultural diets practiced by humans see practice…), physical exercise (Physical exercise is a physical activity practiced in principle…) or medications.
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