dads are also concerned

2023-06-22 11:56:14

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Autism and Dépakine: dads are also concerned

written on June 22, 2023 at 1:56 p.m.

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Article published in the newspaper nº 114

The valproate de sodiumwhich is found in the Depakine, is an antiepileptic whose teratogenic effects (causing fetal malformations), but also on psychomotor developmental disorders and/or autism spectrum disorders in children exposed in utero are (finally!) proven. But if women of childbearing age were primarily warned regarding the dangers represented by valproate for their pregnancy, a study commissioned by the European Medicines Agency (EMA) suggests that fathers would also be concerned. In effect, children whose fathers took valproate three months before conception are more likely to have neurodevelopmental disorders.

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Conducted on the basis of several Scandinavian registers, the study compared children whose father, who had epilepsy, was treated with valproate in the three months preceding conception versus those whose father was treated with other molecules. (lamotrigine or levetiracetam). According to the ANSM, “these results suggest an increased risk of neurodevelopmental disorders, such as autism spectrum disorders, in children whose father was exposed to valproate. This risk varies between 5.6% and 6.3% in children born to fathers exposed to valproate versus 2.5% and 3.6% for children born to fathers treated with lamotrigine or levetiracetam. As a reminder, this risk […] is in the order of 30 to 40% following maternal exposure to valproate “. As always with the ANSMone should not draw hasty conclusions because, according to the gendarmes of the drug, “the limits of this study do not allow at this stage to conclude on this risk “. Procrastination which has already earned the agency an indictment for “injury and manslaughter by negligence “at the end of 2020, in the scandal of… Dépakine. We do not recover.

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