2023-09-21 09:56:37
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Curcumin to replace PPIs?
A recent study published in the scientific journal BMJ highlights the benefits of curcumin once morest certain digestive ailments and gives indications regarding the dosage. Thus, integrating a daily curcumin supplement might be as effective as taking PPIs, but less dangerous.
The dyspepsia is characterized by a feeling of difficult digestion, pain and stomach painsbut also bloating, as well as gastric reflux. This digestive disorder can be triggered by underlying health problems (digestive diseases such as irritable bowel syndrome, which is associated with dyspepsia half the time), factors such as diet and stress. This syndrome can also manifest without any apparent cause, which is referred to as functional dyspepsia. Among the first-line treatments for the symptoms of this disorder, we find proton pump inhibitors (PPIs) (1). However, these same medications can cause… functional dyspepsia, as recalled in the dedicated Health Insurance sheets (2). But that’s not all. In 2021, we echoed the recommendations from the High Authority for Health (HAS) aimed at reducing the inappropriate prescription of PPIs in France due to significant adverse effects. According to HAS estimates, this misuse concerned half of prescriptions in 2020, an alarming situation whereas in 2018, the journal Prescrire reported possible increased mortality risks following three months of use.
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Curcumin to the rescue
The search for other treatments, particularly natural ones, therefore represents a real challenge. In this sense, a new study (3), carried out by a team of Thai researchers, has proven very promising. Carried out on a cohort of 151 people, it compared the effectiveness of taking a 20 mg omeprazole pill (a PPI) per day to that of two 250 mg curcumin capsules taken four times a day. After 28 days of treatment, pain and other symptoms decreased equally for participants taking PPIs and those taking curcumin. After 56 days (and the cessation of treatments for 28 days), the improvement persisted and even increased, and it was similar in both the curcumin group and the PPI group.
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So, although curcumin did not satisfy participants with regard to taste and smell over the long term, it was found to be safe and well tolerated. Thus, it might represent a real alternative to taking PPI in the treatment of dyspepsia. However, any long-term supplementation is not harmless either, including curcumin, it is therefore important to choose the right food supplement and to be accompanied in order to avoid possible adverse effects or interactions. Enough to give food for thought to people suffering from this common pathology.
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