2023-08-19 20:48:58
Recently, news broke that scientists at the Lewis Katz School of Medicine at Temple University in the United States used EBT-001, a CRISPR-Cas9 gene editing technology, to successfully remove SIV (Simian Immunodeficiency Virus) from the genome of non-human primates safely and efficiently. .
The preclinical research, which marks an important step in the field of human HIV treatment, has been published online in the journal Gene Therapy.
In this study, the research team chose rhesus monkeys as the test subjects and used a CRISPR-Cas9 gene editing tool called EBT-001, which can precisely locate the SIV proviral DNA.
Studies have shown that EBT-001 can safely and efficiently remove SIV latent in the virus reservoir from the host DNA, and there is no off-target effect in animals.
The goal of this new technology is to permanently clear the virus in large animal model tissues through a one-time injection treatment. The results of this study confirm the safety of this technology.
Scientists used non-human primates as preclinical test subjects, edited the SIV-specific CRISPR-Cas9 gene editing construct (EBT-001) into the adeno-associated virus 9 (AAV9) vector, and injected it intravenously. into SIV-infected animals.
This breakthrough provides an important reference for the ongoing clinical trials of EBT-101. This is not only an important milestone in the field of HIV research, but also injects power into the development of multiple gene editing therapies for herpes simplex virus, hepatitis B and other infectious diseases.
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