COVID-19 Vaccine Safety Study: Adverse Effects and Risks

2024-02-20 21:30:00

A new international study, the largest to date, on vaccines treating COVID-19 has confirmed previously observed links between this inoculation and increased risks of certain adverse side effects, such as myocarditis and Guillain-Barré syndrome.

The study covered nearly 100 million people vaccinated in eight different countries including Canada: Argentina, Australia, Denmark, Finland, France, New Zealand and Scotland.

Led by the Global Vaccine Data Network organization, the scientific study examined adverse health effects caused by the administration of the Pfizer, Moderna and AstraZeneca vaccines.

The team of experts looked for 13 particularly important health problems that occurred in vaccine recipients up to 42 days after vaccine injections, including Guillain-Barré syndrome, Bell’s palsy, seizures, myocarditis. and pericarditis.

The study, published last week in the journal Vaccinetherefore revealed that the products were linked to a slight increase in neurological, blood and heart medical problems.

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Rare cases of myocarditis, an inflammation of the heart muscle, have been found in the first, second and third doses of the mRNA vaccines from Pfizer-BioNTech and Moderna.

Another heart condition, pericarditis, had a 6.9 times higher risk among those who received a third dose of AstraZeneca’s viral vector vaccine, the study found.

Also, the report notes that a first and fourth dose of Moderna’s vaccine presented a 1.7 times and 2.6 times higher risk of pericarditis, respectively.

There would also be an increased risk of developing a type of blood clot in the brain from a viral vector shot like the one from Oxford University and manufactured by AstraZeneca.

Researchers observed a “significant increase” in cases of Guillain-Barré syndrome, a rare neurological disorder, in people who received the AstraZeneca vaccine.

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Safety indications have been recognized for transverse myelitis, an inflammation of the spinal cord, with viral vector vaccines, as have acute disseminated encephalomyelitis, swelling of the brain and spinal cord, with viral vector vaccines. and mRNA.

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“The safety signals identified in this study should be evaluated in the context of their rarity, severity, and clinical relevance,” the researchers said in the study.

Moreover, according to lead author Kristýna Faksová of the Statens Serum Institute in Denmark, “the size of the population increased the possibility of identifying rare potential safety signals”.

The researchers also noted in their analysis that COVID-19 infections were found to be more likely to cause the observed health problems than vaccination.

According to them, this factor should be taken into account when assessing the benefits and risks. Moreover, several experts have reiterated during the pandemic that the advantages of vaccines outweigh their disadvantages.

More than 13.5 billion doses have been administered worldwide since the start of the pandemic.

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