2023-07-05 11:11:00
Hallym University Dongtan Sacred Heart Hospital Department of Surgery Professor Jong-Wan Kim’s team announced research results
Comparison of colorectal cancer characteristics and chemotherapy prognosis in young vs. elderly patients
Kim Jong-wan, Professor of Surgery, Hallym University Dongtan Sacred Heart Hospital
Colon cancer is one of the most common cancers in Koreans who enjoy spicy and salty food. According to the latest cancer registration statistics (2020), colorectal cancer ranks 4th in men and 3rd in women, all occupying the upper ranks.
In particular, since it is closely related to eating habits, young people are no exception. Young colorectal cancer patients are expected to have a good prognosis if they continue to receive chemotherapy even if the diagnosis is late and the characteristics of the cancer are poor.Research has shown that it can be done. Rather than believing only in youth, it is very important to continue chemotherapythat
Hallym University Dongtan Sacred Heart Hospital, Department of Surgery Professor Kim Jong-wan’s team analyzed the survival rate following treatment of 93 young patients (average age 38.8 years old) and 1899 elderly patients (67.7 years old) over 45 years of age who were diagnosed with stage 0-3 colorectal cancer. As a result, it was confirmed that this was the case.
According to the detailed analysis results, among the two groups, the characteristics of cancer were worse in the younger patient group than in the elderly patient group. Histologically, the rate of cancer with a high degree of malignancy was 11.8% in the young patient group, higher than 5.4% in the elderly patient group. The lymphatic vessel and perineural invasion rates were also 45.2% vs. 38.8%, and 26.9% vs. 18.7%, respectively, indicating that the younger patient group was diagnosed as a worse cancer.
In addition, the younger patient group suffered more bowel obstruction (24.7% vs. 14.2%) and colonic perforation (5.4% vs. 1.7%) due to tumor blockage of the colon than the older patient group, resulting in 16.1% of patients requiring emergency surgery. It was greater than 8.5% in the elderly patient group. In terms of symptoms caused by colon cancer, such as abdominal pain, bloody stool, constipation, weight change, and indigestion, 68.8% of the young patients group experienced more than 55.9% of the elderly patient group. This means that detection and treatment of colorectal cancer is delayed until symptoms appear.
Analysis graph of recurrence-free survival rate between young colorectal cancer patients and old colorectal cancer patients
However, the rate of chemotherapy was higher in younger patients. Factors such as the rate of laparoscopic surgery, complications, and length of hospitalization did not show significant differences between the two groups, but the rate of receiving chemotherapy was 62.4% in the younger patient group and 45.3% in the older patient group. In addition, 20% of the elderly group stopped chemotherapy before completing treatment, but only 8.8% of the younger patient group stopped chemotherapy. The rate of using combination anticancer drugs was also higher in the younger patient group (45.2%) than in the elderly patient group (27%).
As a result of this The younger group of patients with colorectal cancer had a better prognosis, although the cancer was difficult to characterize and diagnosed and treated late.
The 5-year recurrence-free survival rate, which is survival without cancer recurrence following cancer treatment, was 86.7% in the younger patient group, 12.5%p higher than that of the older patient group (74.2%). In particular, as the disease stage increased, the difference widened, reaching 21.7%p: 100% vs. 89.5% in stage 1, 87.4% vs. 75.2% in stage 2, and 82% vs. 60.3% in stage 3.
Professor Kim Jong-wan said, “Through this study, Young colorectal cancer patients received more chemotherapy without stopping than older patients and had a higher recurrence-free survival rate because they used more combination anticancer drugs“The older you are, the more likely you are to be resistant to chemotherapy,” he said. Chemotherapy is a very important treatment process that inhibits the growth of cancer, reduces its size, and completely removes cancer cells so that a cure can be expected.”he emphasized.
Meanwhile, this research paper is titled ‘A Retrospective Multicenter Study of the Clinicopathological Characteristics and Prognosis of Young Adult Patients with Colorectal Cancer: Effects of Chemotherapy on Prognosis’. was published in the latest issue of the Internationally Authoritative SCIE-level Journal of Clinical Medicine (IF (citation index): 4.964).
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