2023-12-31 17:55:08
A study published in The American Journal of Clinical Nutrition, involving 573 older adults, found that cocoa extract supplements improved cognition in participants with poor diets, but had no effect on those with healthy diets. . The research is part of the larger COSMOS trial exploring the health impacts of supplements.
Recent research shows that cocoa extract supplements may benefit cognition in older people with poor diets, but not in those with healthy diets, according to a study conducted as part of the larger COSMOS trial .
Cocoa extract has shown a potential protective effect on cognition, but randomized clinical trials in older adults have yielded inconsistent results. A new cognitive study in a randomized trial, known as the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS), suggests that taking cocoa extract supplements containing 500 mg per day of cocoa flavanols had significant cognitive benefits for older adults with lower usual dietary quality. the time of registration for the study. However, no cognitive benefits were seen in participants who already had healthy eating habits at the start of the study.
The study, conducted by researchers at Mass General Brigham, included 573 older adults who underwent detailed in-person cognitive testing and was published Dec. 7 in The American Journal of Clinical Nutrition.
Study results
Results of detailed neuropsychological assessments carried out over two years showed that daily supplementation with cocoa extract, compared to placebo, had no overall benefit on overall or domain-specific cognitive function. However, secondary analyzes showed that participants with poor-quality diets experienced cognitive benefits from taking the cocoa extract supplement.
The results of this study – which was carried out among COSMOS participants who presented in person for detailed cognitive testing – are consistent with the results of an earlier study that used an online cognitive assessment given over the Internet to a group of COSMOS recruited separately. participants.
COSMOS trial and wider implications
COSMOS is a large-scale, long-term, investigator-initiated clinical trial led by Brigham and Women’s Hospital. More than 21,000 older women and men were enrolled across the United States to participate in this randomized, double-blind, placebo-controlled study to test whether taking daily cocoa extract supplements or common multivitamins reduced the risk of developing heart disease, stroke. , cancer and other significant health problems. Analyzes of COSMOS data continue to provide insights into the links between supplements and human health.
The study was led by Mass General Brigham researchers Dr. Chirag Vyas and Dr. Olivia I. Okereke of Massachusetts General Hospital, as well as Dr. Howard Sesso and Dr. JoAnn Manson of Brigham and Women’s Hospital.
The COcoa Supplement and Multivitamin Outcomes (COSMOS) study is supported by a grant initiated by researchers at the Mars Edge, a segment of Mars dedicated to nutritional research and products, which included infrastructure support and the donation of pills and drugs. study packaging. Pfizer Consumer Healthcare (now Haleon) provided support by partially providing study pills and packaging. COSMOS is also supported in part by grants AG050657, AG071611, EY025623, and HL157665 from the National Institutes of Health, Bethesda, MD. The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute, the National Institutes of Health, the U.S. Department of Health and Human Services through Contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005. Neither Mars Edge nor Pfizer Consumer Healthcare provided comments regarding data analysis, interpretation of results, or development of the manuscript.
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