2023-08-01 04:00:34
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Certain circular RNAs can bind to a cell’s DNA and cause DNA mutations that can lead to cancer. [사진= 게티이미지뱅크]Why do some people get cancer and some people don’t get cancer even though they are in a similar environment or have similar eating habits? Circular RNA (circular genetic fragments) may be the answer to this question, researchers have found.
Researchers in Australia have found a significant link between a person’s cancer risk and the function of circular RNA (circular genetic fragments) found in cells, reported the American scientific research media ‘studyfinds.org’. .
The researchers compared blood tests from newborns with acute leukemia and those without blood disorders.
As a result, they found that certain circular RNAs are present at significantly higher levels in newborns with leukemia even before symptoms appear.
These findings suggest that specific circular RNA molecules present in an individual’s cells are a major factor in the development of cancer-causing or oncogenes.
Circular RNA has the ability to bind to DNA at various locations in other cells. By binding to specific sites on DNA, they break DNA that cells need to repair in order to survive.
Circular RNA can also change the physical location of damaged DNA within the cell nucleus, resulting in the fusion of two different DNA regions. It’s like putting the pages of different books together.
In other words, certain circular RNAs can bind to the DNA of cells and cause DNA mutations that can cause cancer.
The researchers also said, “It seems that several circular RNAs cooperate to cause cleavage at multiple DNA sites.” This process, called chromosomal translocation, poses a significant challenge to cells because it results in gene fusions that can transform normal cells into cancer cells.
Known as ‘ER3D’ (endogenous RNA-induced DNA damage), this revolutionary discovery is credited with opening a new era in medical and molecular biology research.
“This is the first example of a genetic molecule with the ability to mutate its own DNA and cause cancer from within, making it possible to use such a molecule as a therapeutic target and disease marker,” said the researchers. “ER3D is not limited to leukemia, but other It can also be applied to other types of cancer and human diseases.”
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