The Chung Cheng University team established an animal experimental model for prostate cancer bone metastasis, and used imaging to track the growth of cancer cells. (Provided by Chung Cheng University)
Reporter Cai Zongxun / Chiayi report
Cancer patients are most afraid of metastasis. Among them, regarding 70-80% of prostate cancer metastasizes to bone tissue, and the mortality rate remains high. It ranks fifth among the top 10 cancer causes of death. Chung Cheng University has made a major breakthrough in the development of gene therapy vectors, which can be effectively treated Prostate cancer has metastasized to bone and made the tumor size close to 0. The research results have been published in world-renowned journals and applied for human trials. It is hoped that it can be applied to patients as soon as possible and greatly reduce the mortality rate.
Zhang Deqing, a professor at the Department of Biomedical Sciences at Chung Cheng University, said that the incidence of prostate cancer is quite high in men, and cancer cells are more likely to travel through the blood or lymph system to the spine, pelvis and other bone tissues to grow, destroying the bone structure, and cancer cells will spread Prostate cancer tends to be at an advanced stage when bone metastases occur. Most of them use chemotherapy and hormone therapy, but they are prone to drug resistance and have a relatively high mortality rate.
The Chung Cheng University team has been conducting research on the JC virus, one of the human polyomaviruses, for 30 years. It has successfully produced a “JC viroid capsid” as a gene therapy vector through E. “In addition to prostate cancer in situ, Zhang Deqing also conducts gene therapy research on prostate cancer bone metastases.
Using images to track cancer cell growth and treatment effects
The Chung Cheng University team established an animal experimental model for prostate cancer bone metastases. By injecting fluorescent gene prostate cancer cells into animals, images can be used to track the growth of cancer cells and observe treatment effects. The results showed that treatment with two clinical hormone drugs reduced the tumor size to regarding half; the Chung Cheng University team’s gene therapy inhibited the growth of most prostate cancer cells in bone tissue.
Experiments have shown that the gene therapy vector of the Chung Cheng University team can reach the prostate cancer cells that have been transferred to the bones through the blood circulation, and induce the suicide gene of the vector to effectively kill the cancer cells. The research results were published in Gene Therapy, a medical journal under the world-renowned series of natural journals.
Zhang Deqing said that this bone metastasis prostate cancer gene therapy research has long-term cooperation with Shen Zhenghuang, a urologist at Chiayi Christian Hospital, and Wang Meilin, a professor at the Department of Medicine of Sun Yat-Sen Medical University. Bone metastases bring another treatment modality.
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