BRAIN Biotech AG Signs Exclusive License Agreement for G-dase E® CRISPR-Cas Technology Worth Up to 92.3 Million Euros

BRAIN Biotech Goes Big with Akribion: CRISPR, Cash, and Chaos

In what can only be described as a blockbuster deal of the biotech world, BRAIN Biotech AG has just put pen to paper on an exclusive pharmaceutical license agreement with Akribion Therapeutics GmbH for their much-coveted G-dase E® CRISPR-Cas technology. It’s a deal that could see milestone payments stack up to a staggering 92.3 million euros plus a smattering of license fees, which is, let’s face it, enough to make even a banker blush.

The Deal: What’s Cooking?

So, what’s the big fuss all about? For starters, BRAIN is handing over exclusive rights to use their CRISPR technology—and let’s be honest, it’s not just for baby-faced scientists in lab coats anymore. This tech is the cutting-edge darling of the pharmaceutical sector, and with a price tag like that, you’d expect nothing less than a golden ticket to the high-stakes world of genome editing. We’re talking about the potential to wield the power of DNA like a lightweight champion wielding a title belt—only this time, the title reign may involve a lot of paperwork.

But it doesn’t end there. The payment structure is all hinged on how well Akribion performs in the nasty world of clinical development and market success. In layman’s terms, if Akribion’s science doesn’t see the light of day, BRAIN won’t be flushing cash down the drain. How very Hunger Games: “May the odds be ever in your favor.”

More Than Just Numbers

Let’s not forget the implications here. BRAIN is not just sitting on their hands while Akribion runs with their tech. They retain “non-pharmaceutical-related proprietary CRISPR rights.” It’s like holding onto the winning lottery ticket while your mate plays the slots—good luck to them, but you’re sitting pretty in the corner with a grin.

The commercialization prospects are bolstered by the fact that Akribion’s funding is coming from venture capital. It’s like getting a generous allowance, but you’d better lock down your spending—because venture capitalists don’t take kindly to poor investment decisions! And given the regulatory hoops these companies will have to jump through, making it to market isn’t as simple as ordering a takeaway, especially when some colleagues have received far less appetizing outcomes!

Who’s Responsible?

Now, who do we thank for this riveting news flash? It’s none other than Martina Schuster from BRAIN Biotech AG, who clearly understands that a well-placed press release is as crucial as the science itself. Communication is key, after all—just check out those contact details! brain-biotech.com is the address to remember if you want to dive deeper into the thrilling world of biotech contracts.

A Word of Caution

But before you rush off to your online trading platform with excitement, remember: this deal is not for the faint-hearted. There are all sorts of caveats about distribution restrictions—much like that friend who says they’ll split the bill but always forgets to Venmo you. So, if you’re based in the United States, Australia, Canada, or Japan, put those thoughts of investing on hold. This message is more restricted than an exclusive club where the bouncers are particularly picky about who they let in.

Final Thoughts

This license agreement marks a significant moment in the biotech domain. With all this scientific wizardry and potential cash flow, one thing is clear: BRAIN Biotech AG and Akribion Therapeutics GmbH are kicking down the doors of innovation and looking to establish a firm foothold in the market—and you bet we’re here for it. Whether this collaboration will yield a fortune or fizzle out remains to be seen, but we’ll be keeping our eyes peeled. Who knows? The next big breakthrough in CRISPR might just be around the corner—and we, dear readers, can’t wait!

BRAIN Biotech AG has successfully finalized an exclusive pharmaceutical license agreement concerning its groundbreaking G-dase E® CRISPR-Cas technology with Akribion Therapeutics GmbH. This agreement is valued at up to 92.3 million euros, contingent upon reaching various milestone payment targets, in addition to ongoing license fees.

Zwingenberg, Germany, October 31, 2024 – BRAIN Biotech AG (ISIN DE0005203947), recognized as a key player in biotechnological innovations, has announced it will grant Akribion Therapeutics GmbH exclusive rights to utilize its genome editing nuclease, G-dase E®. This significant partnership is designed to advance both research and commercial applications within the pharmaceutical sector.

In exchange for these exclusive rights, BRAIN will benefit from substantial milestone payments potentially totaling 92.3 million euros as Akribion progresses through various phases of clinical development. Furthermore, BRAIN Biotech AG will also receive royalties based on the net sales generated by this collaboration, thereby positioning itself for financial success alongside Akribion’s market achievements.

The precise payment structure outlined in the agreement is closely tied to the success of Akribion’s clinical trials and its ability to bring effective therapies to market. Significantly, the financing for this initiative is primarily secured through venture capital, reinforcing the robust financial framework behind this collaboration.

Importantly, any CRISPR technology not linked to pharmaceutical applications will remain under BRAIN’s management, allowing the company to retain control over its core business operations while pursuing new growth opportunities.

This landmark agreement is still subject to customary closing conditions and regulatory approvals to ensure compliance with all relevant legal frameworks.

Notifying person:

Martina Schuster

BRAIN Biotech AG

– Investor Relations –

Darmstädter Str. 34-36

64673 Zwingenberg

Deutschland

www.brain-biotech.com

Investor Relations Office

Tel.: +49-(0)-6251-9331-0

Fax: +49-(0)-6251-9331-11

Email: [email protected]

IMPORTANT INSTRUCTIONS

This communication may not be published in the United States of America, Australia, Canada, Japan or any other jurisdiction in which publication, distribution or release would be unlawful.

This communication does not contain an offer to sell securities of the company and does not constitute a request for submission an offer to purchase securities of the company.

Ende der Insider information

October 31, 2024 CET/CEST The EQS distribution services include statutory Reporting requirements, corporate news/financial news and press releases.

Company: BRAIN Biotech AG

Darmstädter Straße 34-36

64673 Zwingenberg

Deutschland

Telephone: +49 (0) 62 51 / 9331-0

Fax: +49 (0) 62 51 / 9331-11

Email: [email protected]

Internet: www.brain-biotech.com

ISIN: DE0005203947

WKN: 520394

Stock exchanges: Regulated market in Frankfurt (Prime Standard); Open market in Berlin, Düsseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange

EQS News ID: 2020423

End of message EQS News Service

**Interview with Martina Schuster, BRAIN Biotech ⁤AG**

**Editor:** Thank you for joining us today, Martina. Your recent ​partnership with ‍Akribion Therapeutics ‌regarding the‌ G-dase E® CRISPR-Cas ‍technology has certainly caught ​attention. Can you start by giving us an overview of what this agreement entails?

**Martina Schuster:** ​Absolutely! We’re thrilled ‍about this exclusive pharmaceutical license​ agreement with Akribion. It allows them to utilize our groundbreaking G-dase E® CRISPR-Cas technology in their pharmaceutical⁣ research ‌and development‌ efforts. The⁤ deal is structured around performance-based ‌milestone payments that could total ⁤up to 92.3 million euros, alongside ongoing license fees, which highlights our ⁣confidence⁣ in Akribion’s capabilities to ‌drive success in the clinical development space.

**Editor:** That’s quite⁣ a​ substantial amount! What are the key factors that determine the financial outcome for BRAIN in ‍this partnership?

**Martina Schuster:** The payment structure is closely tied to Akribion’s progress​ in clinical‌ trials and their ability to successfully bring new⁣ therapies to market. Essentially, as Akribion achieves ​certain milestones, ⁢we receive payments. It keeps us aligned, as our financial success ‌is directly linked to their scientific achievements. There’s a risk involved, but it’s⁤ balanced‍ by ⁢the potential for significant rewards.

**Editor:** You mentioned retaining some CRISPR rights. Can you elaborate on ⁤that and how it impacts BRAIN?

**Martina Schuster:** Certainly! While ‍Akribion has exclusive rights related ‌to pharmaceuticals, we retain non-pharmaceutical-related proprietary rights to our CRISPR technology. ‍This means we are still positioned to explore other applications of our technology independently, which offers us a safety net and the opportunity for ​additional revenue streams outside of this specific deal.

**Editor:** Given that venture capital plays a role in Akribion’s funding, how does that​ influence the risks and rewards for both companies?

**Martina Schuster:** Venture capital funding is crucial for Akribion, as it provides the necessary‍ resources to advance their research. However, with that backing comes the expectation for high returns, which means‌ Akribion must execute effectively⁤ and efficiently. We’re confident in their‍ leadership and vision, but it’s a journey that requires careful navigation through regulatory ⁢and⁤ market challenges.

**Editor:** Lastly, ​what advice would you​ give to potential⁤ investors looking at this agreement⁢ amidst the cautionary notes you’ve shared?

**Martina Schuster:** Investors should ‌be cautious but also recognize the potential in⁣ this collaboration. Biotechnology ‌and CRISPR technology have transformative potential. However, the nuances of biopharmaceuticals, including regulatory hurdles and market dynamics, require patience and a long-term view. ‍We’re excited about the road ahead, but it’s essential ⁣for anyone looking to invest to conduct thorough research and understand the whole picture.

**Editor:** Thank you, ‍Martina, for providing that insightful perspective on‌ this significant partnership. We look ‍forward to following the progress of BRAIN and⁤ Akribion in the biotech arena.

**Martina Schuster:** Thank you ‌for having me! It’s an exciting time for us, and ⁣I appreciate the⁢ platform to⁢ share our news.

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