2023-05-10 05:51:59
Mental health score improved by 2.68 times compared to the control group… Reduce anxiety/anxiety
Phototherapy using light has been shown to be effective in improving cognition in dementia patients.
As a result of the meta-analysis, it was revealed that dementia patients who received light therapy experienced significant cognitive improvement compared to those who received general treatment. However, there was no significant difference between the study groups in terms of improvement in depression or sleep problems.
Meta-analysis is a statistical analysis method that increases the power (probability of making a correct decision) and precision by integrating the results of individual studies.
The research team, led by Professor Xin Lian Lu of Peking University’s School of Psychological and Cognitive Sciences, performed light therapy on a total of 766 dementia patients, including 426 in the phototherapy group and 340 in the control group. The average age of these participants ranged from 73.7 to 85.9 years, and there were more women than men.
Seven of the studies used normal daily lighting in the control group, and the remaining studies were conducted in dim lighting of 50 lux or less or no light.
Considering that the brightness of a living room with the lights turned off on a sunny day is 300 to 600 lux, and the brightness of a living room with indoor lighting turned on on a sunny day is 600 to 1,000 lux, 50 lux is quite dark.
The research team investigated the effect of phototherapy on depression along with cognitive function in patients.
The study focused on the Mini-Mental State Examination (MMSE) and, as secondary outcomes, the Dementia Behavioral and Psychological Symptom Scale (BPSD), the Corner Depression Scale (CSDD), the Cohen-Mansfield Agitation Index (CMAI), and the Neuropsychiatric Index (NPI). , total sleep time (TST), sleep efficiency (SE) or list of sleep disorders (SDI).
As a result of the investigation, there was a ‘remarkable positive effect’ on global cognitive function, such as a 2.68-fold improvement in the MMSE score of the phototherapy group compared to the control group. Especially among patients with high CMAI scores exhibiting severe agitation behavior, there was a tendency for CMAI scores to decrease after light therapy.
On the other hand, the corner depression scale CSDD was -0.7, so no significant effect was demonstrated, and there were no significant differences between the two groups in the TST, SE, and SDI scores.
Side effects of phototherapy are rare and not serious. Of the 426 patients, 2 experienced mild eye irritation and 1 had transient flushing of the forehead.
Professor Xin Lian Lu said, “Due to limitations such as limited efficacy and side effects, drug treatment for dementia is recognized as an important part of comprehensive dementia treatment.” Phototherapy is a non-invasive, inexpensive and safe ‘non-pharmacological treatment’.”
The research team said, “Light compensates for the decrease in visual sensory input in dementia patients and stimulates specific neurons in the brachial nucleus of the hypothalamus to regulate circadian rhythm.” Supplementation serves as an optimal condition for cognitive enhancement.”
The results of this study were published in the latest issue of the scientific journal Brain and Behavior.
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