Mangala, who was cautioned in the 29th minute, was replaced in the 63rd minute by former Brugeois Emmanuel Dennis, in a game whose goals were scored by Marcus Rashford (19th), Anthony Martial (22nd) and Fred ( 87th).
Manchester United are in 5th place in the standings, with 29 points in 15 matches. Nottingham Forest are 19th and penultimate with 13 units.
In the Championship, Vincent Kompany’s Burnley lined up a 4th victory in a row by beating Birmingham 3-0 on the 24th day of the English D2. The Clarets retain the lead with 50 points, 3 more than their runner-up Sheffield United.