2023-08-03 16:07:23
American researchers have developed a targeted molecule, but still under test, which seems to disrupt DNA replication and repair in cancer cells, without affecting healthy cells.
An investigational chemotherapy product is currently undergoing a clinical trialPhase 1 clinical trial.” The results are promisingsaid researchers from City of Hope, one of the largest cancer research and treatment organizations in the United States. AOH1996 cancer pill can suppress tumor growth as monotherapy or as combination therapy in cellular and animal models, without causing toxicity ».
“In combined treatment” because the experiences reported in the study showed that the experimental product increased the sensitivity of cancer cells to chemicals that cause DNA damage — such as the chemotherapy drug cisplatin.
A drug targeted at cancer cells
In detail, proliferating cell nuclear antigen (ANCP) is essential for DNA replication and repair processes. Researchers have found that, in its mutated form, ANPC is one of the potential causes of increased nucleic acid replication errors in cancer cells. ” This allowed us to design a drug that uniquely targets the ANPC form in cancer cells. “, explain the authors. The test product caused the death of cancer cells (called “apoptoseapoptosis”), without affecting healthy cells.
Of note, AOH1996 has been shown to be effective in preclinical research by treating cells derived from breast, prostate, prostate, cerebrum, ovaryovaries, cervix, skin and lung cancers.
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