2023-09-15 00:28:39
According to a Swedish study, taking vitamin C and other antioxidants in the form of dietary supplements can stimulate the formation of new blood vessels in lung tumors.
THE food supplements containing antioxidants such as vitamin C might accelerate tumor growth and metastasis, according to the study of the study of Karolinska Institutet published August 31 in The Journal of Clinical Investigation. “We discovered that antioxidants activate a mechanism that causes cancerous tumors to form new blood vesselswhich is surprising, because Antioxidants were previously thought to have a protective effect, commented Martin Bergö, head of the study and vice-president of the Karolinska Institutet in Sweden. THE new blood vessels nourish tumors and can help them grow and spread.”
How is it possible ?
Professor Bergö’s research group had already shown that antioxidants like vitamins C and E might accelerate the growth and spread of lung cancer by stabilizing a protein called BACH1. BACH1 is notably activated when the level of oxygen free radicals decreases, which happens when we take antioxidant supplements to counter the harmful effect of free radicals on the body. By studying organoids – small microtumors cultured in patients – but also mice and samples of human breast and kidney tumors, scientists have now shown that BACH1 activation induced the formation of new blood vessels what is called angiogenesis. A finding that raises concerns regarding the excessive use of dietary supplements containing antioxidants, particularly in patients with cancer or at high risk of cancer.
“Most people do not need additional amounts of antioxidants”
The researchers emphasize, however, that the harms are observed with “doses too high” antioxidants. “There is no need to worry regarding the presence of antioxidants in the normal diet, but most people do not need extra amounts of them,” a underlined Professor Bergö. What the French health authorities confirm: “Taking a food supplement will be justified to cover a nutritional need that cannot be covered by common foods” argue l’Considered on its site before recalling that “the consumption of food supplements is not not a trivial act” and “any food supplement should be taken beforehand discussed with a healthcare professional”. The Swedish researchers hope that this study paves the way for more effective treatments to prevent angiogenesis. They also highlight the need for continued research to assess the clinical relevance of these results in other types of cancers.
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