Another step forward! A 66-year-old US man has recovered from his fourth HIV infection following a stem cell transplant.
Human immunodeficiency virus (HIV) destroys the body’s immune system. This can lead to AIDS. The body is struggling to fight infection. On July 28, the foreign news agency reported. One of the important evolutions of mankind is the cure of sexually transmitted diseases until returning to daily life as usual.
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A 66-year-old man who did not want to be identified. became the oldest patient4th person recovered from HIV infection in the world After receiving a stem cell transplant to treat blood leukemia from donors who are naturally resistant to the virus
The man known as the patient “City of Hope” by location in the US in the city of Duarte california which is the patient who has been infected with HIV the longest as well Diagnosed in 1988, many of his friends died of HIV at the time, stating: ‘Didn’t expect to see that day’
In a statement the man said,When I was diagnosed with HIV in 1988, like many others, I thought it was the death penalty. I never thought I would live to see the day I was no longer infected with HIV.”
For over 30 years, he received antiretroviral therapy (ART) to control his condition. Later, his body no longer has HIV. and HIV had not appeared in his body for over 17 months. HIV had not been cured through direct treatment. Rather, it was because he was treated for leukemia recently diagnosed at the age of 63.
At the beginning of treatment, the doctor plans toTreat leukemia with a bone marrow transplant to replace cancerous blood cells. Ready to seek donors who are resistant to the virus that causes AIDS. which is the first working mechanism to cure “Patients in Berlin” Timothy Ray Brown in 2007 provided the opportunity for doctors to use gene editing to create mutations and heal patients.
The patient was transplanted from an unrelated blood donor in 2019 following being diagnosed with acute myelogenous leukemia. His doctor selected donor stem cells with genetic mutations found in regarding 1 in 100 people of Northern European descent.
HIV normally enters the white blood cells through a small channel known as ‘CCR5’. The body (including the donor) has so mutated that the CCR5 gap closes, thus causing the body to able to resist HIV infection untilThe man no longer had HIV in his body.
Scientists think the process works because donor stem cells carry a particularly rare genetic mutation. After the transplant three and a half years ago. After chemotherapy, the City of Hope patient stopped taking ART in March 2021. He has now been in remission from both HIV and leukemia for more than a year. the research team said
Doctors who presented data ahead of the International AIDS Association (IAS) 2022 meeting said the case provides access to treatment for older patients with HIV and leukemia. Especially since the stem cell donor is not a family member. It is possible one day to effectively cure more people using gene editing techniques to create mutations might take decades.
Prof. Sharon Levin, President of the International AIDS Society “City of Hope” provides continued hope and inspiration for people living with HIV and the wider scientific community. Although treatment is unlikely to be an option for most people with HIV due to the risks of the procedure.
Dr. Jana Diktor, an infectious disease doctor, also reiterated that “It’s a complicated procedure and has potential side effects. Therefore, it is not the right choice for most people living with HIV.” However, researchers are looking at targeting methods using gene therapy or genetic modification as potential treatments.
But before the meeting starts on Friday. The United Nations Joint Program on HIV and AIDS (UNAids) has released data showing that the COVID-19 pandemic has hindered efforts to address HIV worldwide. including the reversal of progress in the world’s most populous region. Asia and the Pacific
The report stated that The hard-earned progress was halted. Putting millions of lives at risk The number of new HIV infections around the world has been declining for years. but began to increase in parts of Asia and the Pacific which before the outbreak was less and continued to decline
The number of people treated for HIV has grown slower than in the past decade. The inequality was widening every two minutes last year. A teenage girl or woman is more likely to contract a new HIV infection. 3 times more than boys and men of the same age The report found 650,000 deaths from AIDS last year.
Matthew Kavanaugh, Deputy Executive Director of UNAids, said: “This is a warning signal to the world. spread of covid-19 has greatly undermined the response to AIDS. The UN is targeting less than 370,000 new HIV infections by 2025. Last year, there were regarding 1.5 million cases.”
“This means that there has to be a huge turnaround to reach that goal. Yet low- and middle-income countries lack the necessary $8 billion in capital. as international aid has declined.”
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