2024-10-15 23:10:00
An independent analysis of data from 30,423 patients treated at the Institut Hospitalo-Universitaire Méditerranée Infection (IHUM) revealed even more positive results than those initially reported by IHU researchers. Led by a multidisciplinary team under the direction of Professor Christian Perronne, this study looked at the effectiveness of early treatments administered to these patients during the critical phase of the pandemic. The researchers extensively examined the data to assess the impact of dual therapies used at the IHU, consisting mainly of hydroxychloroquine and azithromycin.
The objectives of the independent study
This analysis was led by a team including Valère Lounnas (PhD in theoretical chemistry), Professor Eleftherios Gkioulekas (applied mathematics), Dr Marc Rendell (physician), Dr Alexis Lacout and Xavier Azalbert (econometrician). Their objective was to independently verify the effectiveness of treatments using rigorous methodology and advanced statistical tools. The work focused on data collected between March 2020 and December 2021, during the acute phase of the Covid-19 pandemic.
The AP-HM, headed by François Crémieux, had authorized the use of the data for the purposes of scientific publications. This made it possible to refute the accusations of Professor Molimard, who had described this study as a “wild trial”. In reality, the study was registered in the AP-HM processing activities register, confirming its legal and scientific nature.
The results of the analysis of early treatments
The results of the analysis showed a 58% reduction in the risk of transfer to intensive care or death thanks to dual therapy consisting of hydroxychloroquine and azithromycin, sometimes combined with ivermectin. This conclusion corroborates previous publications by IHU researchers, demonstrating the indisputable effectiveness of early treatments.
The team reviewed potential biases and factors influencing treatment effectiveness within the limits of available data. The study used multivariate logistic regression analyzes to adjust the results and identify possible interactions between treatments and variables such as age, sex or the presence of comorbidities. No adverse interactions were detected, reinforcing the credibility of the results.
Confirmation of IHU conclusions and new perspectives
The study by Lounnas et al. constitutes the first independent analysis validating the results obtained by the IHU-Mediterranean teams. According to Professor Perronne, this independent validation is a crucial step to reestablish the truth about the effectiveness of early treatments and to encourage other researchers to pursue similar investigations. He underlined the importance of the mathematical and methodological rigor applied to this analysis, which made it possible to demonstrate with certainty the benefits of the treatments.
The results are all the more important as the health authorities seem to want to discredit this data with often circular arguments. The publication of these results by the independent team underlines that early treatments could have avoided a considerable number of deaths, in France as elsewhere.
Estimated lives that could have been saved
The study estimates that if these treatments had been systematically applied, up to 58.1% of deaths linked to Covid-19 could have been avoided. In France, this would correspond to around 97,400 lives saved out of the 167,642 deaths attributed to the pandemic. Globally, this proportion would represent more than 4 million lives.
Analysis conclusions and recommendations
The results of this independent study highlight the effectiveness of early treatments administered at IHU-Mediterranean Infection and highlight the need for a thorough reassessment of the health measures adopted during the pandemic. The multidisciplinary team recommends that additional analyzes be carried out, and calls for a parliamentary inquiry to more precisely estimate the impact of early treatments on mortality linked to Covid-19.
Source : www.francesoir.fr
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