(Taiwan English News/Comprehensive report by Zhu Mingzhu)The latest research in the United StatesHigher vitamin D supplementation in adults with “prediabetes” was found to be associated with a lower risk of developing type 2 diabetes. The study was published in the “Annals of Internal Medicine” on the 7th.
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In order to assess whether taking vitamin D can reduce the risk of diabetes in patients with “pre-diabetic symptoms”, researchers from Tufts Medical Center in Massachusetts, USA, recruited 4190 adult subjects and randomly assigned them After 3 experimental groups and 1 control group, clinical trials were carried out for 3 years.
According to the study report, a total of 2,097 adults were included in the experimental group (taking vitamin D), of which 475 had “pre-diabetic symptoms”; two groups used inactive vitamin D3, and the other group used active vitamin D. Of the 2,093 people in the control group (taking a placebo), 524 had “prediabetic symptoms.”
The results of the mixed analysis showed that compared with the placebo group, the vitamin D supplementation group reduced the relative risk of diabetes by regarding 15%, and the absolute risk was reduced by 3.3%, even allowing patients with abnormal blood sugar to return to normal blood sugar.
So the study authors estimated that, when extrapolating their findings to the more than 374 million adults with “prediabetes” worldwide, vitamin D supplementation might delay the onset of diabetes in more than 10 million people.
In this regard, Li Tingwei, director of the Metabolism Department of the Department of Internal Medicine of Wanfang Hospital, Ou Hongyi, director of the Diabetes Prevention Center of Chengda Hospital, and Xie Boxuan, professor of Physiology and Biophysics at the National Defense Medical College, all put forward their analysis. Experts pointed out that the study used high-dose vitamin D, which is not suitable for ordinary people, and high-dose vitamin D may increase the risk of hypercalcemia, hyperuria or kidney stones.
Ou Hongyi said that although the results of the study pointed out that only in groups with low or insufficient blood vitamin D levels, vitamin D supplementation can have the benefit of preventing “pre-diabetes” from progressing to diabetes, but he reminded that in the study, vitamin D supplementation was seen in patients Afterwards, the average blood levels achieved were higher than the generally recognized safe range, and even reached the levels considered “possibly harmful” in the past. In terms of blood sugar balance, it is necessary to consider what the reasonable concentration of vitamin D is.
Xie Boxuan said that the subjects of the study were patients “with pre-diabetic symptoms”, rather than results that the general public can refer to. Therefore, this study does not prove that vitamin D supplementation in the general public can effectively reduce the risk of diabetes.
In addition, the pre-diabetic patients in the study used vitamin D doses up to 1200 international units (IU) and maintained a high blood vitamin D concentration, which seemed to reduce the incidence of diabetes, but long-term use might easily cause hypercalcemia and hyperhemuria, etc. related toxic reactions.
Xie Boxuan added that the recommended daily dietary dose of vitamin D is 400 to 600 international units (IU), and this dose range cannot reach the dose that effectively reduces the incidence of diabetes in the research.
Li Tingwei pointed out that the study analyzed active and inactive vitamin D together. He felt a little doubtful, because inactive vitamin D3 can be used as a nutritional supplement for the general public, but active vitamin D is prescribed by doctors. dangerous, it is recommended to consult a professional physician first.
Finally, Hongyi Ou concluded that although the research provided scientific evidence that vitamin D can prevent “pre-diabetes” from progressing to diabetes, the benefits are limited to strictly screened “pre-diabetes” patients, not the general public. Therefore, he suggested that the general public does not need to rush to supplement vitamin D, and let more research reports in the future verify these results and safety.
※Source: Taiwan Technology Media Center※
