2023-08-11 08:10:21
August 11, 2023
Espresso might prevent the accumulation of Tau protein in neurons, a phenomenon implicated in the development of Alzheimer’s disease. Explanations.
Espresso, or espresso, is a short coffee with a very strong aroma. And according to a recent study, it might be effective once morest Alzheimer’s disease. The results of this work, recently published in the Journal of agricultural and food chemistryhave shown that the components of espresso would be able to inhibit the aggregation of the Tau protein in neurons, a phenomenon involved in the development of Alzheimer’s disease. “In healthy people, tau proteins help stabilize brain structures, but when certain diseases develop, the proteins can accumulate into fibrils”say the Italian researchers who conducted the study.
According to some scientists, preventing the accumulation of this protein would reduce the symptoms of the disease. While several recent studies suggest that coffee has beneficial effects once morest neurodegenerative diseases, Italian researchers wanted to know if espresso might play this preventive role.
An incubation of 40 hours maximum
So they went to stock up on coffee beans and brewed espressos – regarding 30ml of hot water squirted through 7 grams of finely ground coffee. After analyzing the composition of coffee, they chose to pay particular attention to the effects of caffeine, trigonellin, genistein and theobromine.
The tests were then carried out in vitro, in the laboratory. These molecules but also a full espresso were left to incubate for a maximum of 40 hours with a shortened form of Tau protein. “As the concentration of espresso, caffeine or genistein extract increased, the Tau fibrils were shorter and did not form larger plaques, with the full espresso extract showing the best results. more spectacular, say the researchers in a statement. “The shortened fibrils were found to be non-toxic to cells and not indicative of further aggregation.”
For scientists, these discoveries open the way to new avenues of research once morest Alzheimer’s disease.
To note : According to WHO figures, 55 million people in the world are affected by dementia. Alzheimer’s disease is the most common and is thought to be the cause of 60 to 70% of cases. In it is estimated that 1.2 million people are affected.
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Source : Journal of agricultural and food chemistry, 19 juillet 2023, Ameli.fr, OMS
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Written by : Dorothée Duchemin – Edited by: Emmanuel Ducreuzet
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