2024-06-13 08:35:50
Give infants three days of age a dose of Beyfortus vaccine, a medication that stops bronchiolitis. September 22, 2023, Antoine-Béclère Hospital, Clamart (Hautes-Seine).
Following Beyfortus in 2023, a brand new product will improve the power to combat bronchiolitis. In an opinion revealed on Thursday, June 13, the Well being Service (HAS) advisable the usage of Pfizer’s Abrysvo vaccine towards respiratory syncytial virus (RSV), which is answerable for three quarters of bronchiolitis instances The illness blocks the bronchioles, the narrowest branches of the respiratory system — a illness that’s significantly harmful for infants.
A substitute for nirsevimab (marketed as Beyfortus), the mechanism of which is completely different in that it doesn’t inject the antibodies instantly into the new child like Beyfortus, however somewhat vaccinate the mom within the eighth month of being pregnant in order that she’s going to develop antibodies to those Antibodies are handed to the kid throughout the placenta, offering safety within the first few months of life.
Members of the HAS Technical Committee on Vaccination (CTV) relied on laboratory-transmitted vaccine effectiveness information to evaluate the product’s particular person and collective advantages: an 81.8% discount in extreme RSV infections and a 67.7% discount in hospitalizations. Bronchiolitis is a significant problem, affecting 30% of kids beneath 2 years of age yearly. If the epidemic is critical, pediatric companies, which have been in structural disaster for a few years, will quickly be saturated, leading to infants being transferred to different departments, as was the case just lately within the winter of 2022-2023 and within the winter of 2019.
Strengthen monitoring
Nonetheless, French specialists are extra cautious than the European Medicines Company, which granted Abrysvo advertising authorization in July 2023. They suggest that pregnant ladies obtain the vaccine between 32 and 30 weeks of amenorrhea (ie, the sixth week of amenorrhea). within the eighth month, whereas the European company approves it from the sixth month of being pregnant.
This warning may be defined by an unlucky precedent. Two years in the past, GlaxoSmithKline Laboratories needed to abandon scientific trials of an RSV vaccine for pregnant ladies that was thought of a twin to the Pfizer vaccine. for what? Kids born to vaccinated moms had extra untimely births and deaths than moms who obtained a placebo. With out figuring out the precise trigger, the outcomes are sufficient to render the product substandard.
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