A New Mosquito-Delivered Vaccine Shows Promise in Malaria Fight
Genetically Weak Parisite May Be the Key to Stronger Immunity Against Deadly Disease
“These crippled parasites are administered through a mosquito bite and reach the human liver as usual,” says vaccinologist Meta Roestenberg of Leiden University. “But because the gene is turned off, this parasite cannot complete its development in the liver, cannot enter the bloodstream, and thus cannot cause disease symptoms.”
A new vaccine development against the deadly disease comes promising findings, a potent new weapon against malaria.
In this quest, researchers in the
How It Works
The new vaccine, dubbed GA2, is the second generation of a vaccine against malaria. The difference; its creators used a weakened version. Eight out of nine test subjects were protected from Malaria.
This is compared to only one out of eight protected by the previous generation vaccine version.
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A new approach to Malaria confronts the challenges it mentioned.
this novel approach mimics natural transmission — Delivered via mosquito bite. Gazing Decades
This method allows the vaccine delivers to mimic a natural infection.
“Meanwhile, this crippled infection does create a strong immune response in the liver, which can protect the person from a real malaria infection in the future,” explains Roestenberg.
“That gives the immune system more time to recognize what it is,
The ”
After receiving the GA2 vaccine, it takes following building up immunity. This is
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What are the safety considerations and potential risks associated with receiving a vaccine through a mosquito bite?
## A Stinging Solution: GA2 Vaccine Promises New Hope
**Interviewer:** Dr. Roestenberg, your new GA2 vaccine is showing great promise in protecting against malaria. Could you explain how this innovative approach delivers protection?
**Dr. Roestenberg:** Absolutely. GA2 represents a significant leap forward in malaria vaccination. It uses a weakened form of the malaria parasite, delivered through the bite of a genetically modified mosquito. This mimics how malaria naturally infects the body, but crucially, this weakened parasite can’t cause disease. It reaches the liver, just like the real parasite, triggering a robust immune response without making the individual sick.
**Interviewer:** So, the vaccine essentially trains the immune system to recognize and fight off the actual malaria parasite?
**Dr. Roestenberg:** Exactly. By simulating a natural infection, GA2 allows the body to develop a strong defence against malaria without the risk of illness. We’ve seen remarkable results in our trials, with eight out of nine participants showing protection.
**Interviewer:** This is certainly a significant development, but some may be hesitant about receiving a vaccine delivered through a mosquito bite. What would you say to those individuals?
