Muscle aging is a natural process that affects everyone, resulting in a loss of muscle mass, strength and endurance with age, and is associated with an increased risk of falls and physical disabilities.
In this regard, a study conducted by Nottingham Trent University in cooperation with the Swedish Karolinska Institute, Karolinska University Hospital and Anglia Ruskin University provides new insights into the genes and mechanisms responsible for muscle aging, as it is believed that scientists have found new targets for developing drugs that help treat this condition, including Sarcopenia, which causes increased muscle loss.
The study included analysis of gene expression data for two groups: younger adults (21-43 years) and older adults (63-79 years) in the context of muscle aging and resistance exercise.
Using artificial intelligence techniques, the team was able to identify the 200 genes that most influence aging and exercise, while analyzing the strong interactions between them.
The team observed that one gene, USP54, plays a vital role in muscle aging and deterioration in older people. The importance of this gene was confirmed by a muscle biopsy performed on elderly people, where it showed significant expression.
Scientists have also discovered a number of potential genes linked to resistance exercise.
Although more research is needed, the team believes that these findings may contribute to the development of exercise strategies aimed at preserving muscle mass in older people, which may help reduce the risk of falls and disabilities.
This study, published in the journal Cachexia, Sarcopenia and Muscle, also highlights the potential of artificial intelligence to advance our understanding of muscle aging and loss.
The team hopes to use the results to delay the effects of aging.
Source: Medical Express
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