Japan.. Developing a new method to deliver medicine to the memory center in the brain

An article written by the scientists who developed the new method and published in the magazine stated: “We have developed an approach that allows the use of insulin-like protein molecules to deliver the drug to the hippocampus, which is the memory center in the brain. “This system will improve the effectiveness of Alzheimer’s medications and facilitate their delivery to the brain.”

The scientists pointed out in the article that “neurons in the hippocampus are the first cells that begin to die en masse and encounter performance problems during the development of Alzheimer’s disease and other neurodegenerative diseases, and current typical drugs for dementia are either unable to penetrate the brain, or do not accumulate in the hippocampus.” . To solve this problem, we developed a yeast protein that uses insulin’s capabilities to penetrate this area of ​​the brain.”

This discovery led scientists to the idea that insulin analogues could be used as a kind of “encapsulation” that allows various drugs to treat dementia and other neurodegenerative diseases to be delivered to the hippocampus region of the brain. Guided by this idea, scientists studied how insulin interacts with blood vessel cells and hippocampal neurons.

These studies were conducted by a team of neuroscientists led by Noriyasu Kami, an assistant professor at Gakuin University in Kobe, Japan. While studying how short signaling protein molecules penetrate and spread throughout human brain tissue, scientists discovered that the hormone insulin cannot penetrate the barrier that separates the bloodstream from… Not only the nervous system, but it also accumulates in the hippocampus area of ​​the brain.

Source: TASS