2024-05-15 22:00:00
information That is what a research printed within the journal Nature Nanotechnology reveals: scientists from the Swiss Federal Institute of Expertise Zurich (ETH Zurich) have developed an antidote able to decreasing the results of alcohol earlier than it reaches the liver and the bloodstream. The way it works ?
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How does the physique break down alcohol?
As soon as ingested, alcohol passes via the abdomen and intestines the place it infiltrates the circulation. As soon as within the blood, it reaches the mind inside 10 minutes. You then really feel its results kind of intensely relying on the portions and kind of drinks ingested: leisure, alteration of the senses, exuberant habits, coordination issues, confusion, nausea, vomiting, blackouts, and so on.
The blood additionally carries alcohol to the liver the place it should be damaged down. To beat this, the liver should first rework alcohol into acetaldehyde. This substance is very poisonous and carcinogenic. It alters the functioning of liver cells and tissues, which might trigger irritation, fibrosis or in additional severe instances, cirrhosis. Acetaldehyde is then transformed into acetic acid.
See additionally the article: What does alcohol do to your liver?
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Quickly an antidote to neutralize the poisonous results of alcohol?
A group of researchers from the ETH Zurich in Zurich has developed an antidote to neutralize the unintended effects of alcohol consumption in mice. They managed to develop a protein-based gel able to breaking down alcohol molecules within the gastrointestinal tract. Alcohol is instantly transformed into innocent acetic acid earlier than reaching the bloodstream.
“The gel strikes the breakdown of alcohol from the liver to the digestive tract. In contrast to the metabolization of alcohol within the liver, no dangerous acetaldehyde is produced as an intermediate product,” explains Professor Raffaele Mezzenga from the Meals and Comfortable Supplies Laboratory at ETH Zurich.
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Promising leads to mice
Checks carried out in mice present that the gel reduces blood alcohol ranges by as much as 50% and protects the physique from injury. Much less acetaldehyde accrued in these mice, and stress reactions of their livers had been considerably diminished.
Different organs, such because the spleen or gut, and their tissues had been additionally a lot much less broken by alcohol.
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What are the boundaries of motion of this anti-alcohol gel?
The gel is barely efficient so long as alcohol stays within the gastrointestinal tract. Which means that it won’t have an impact if alcohol poisoning has already occurred (as soon as the alcohol has handed into the bloodstream). It additionally doesn’t assist scale back alcohol consumption typically.
“It is more healthy to not drink alcohol in any respect. Nonetheless, the gel might possibly be notably attention-grabbing for individuals who don’t wish to surrender alcohol utterly, however who don’t wish to put a pressure on their physique and who don’t actively search the results of alcohol,” explains Raffaele Mezzenga . Certainly, the gel additionally reduces the intoxicating results felt when consuming alcohol.
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Sooner or later, the gel might possibly be taken orally earlier than or throughout alcohol consumption. Though additional testing is required earlier than the gel can be utilized in people, the researchers are assured these can be a hit and have already filed a patent utility for the gel.
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See additionally the article: What drinks do you have to substitute alcohol with?
Sources :
Final up to date: Might 2024
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