2024-04-19 11:00:04
Researchers at Nagoya University in Japan have made a significant breakthrough in understanding premature aging. Published in Nature Cell Biologytheir study reveals the role of aldehydes, metabolic products deriving from substances such as alcohol, pollution and the smokein L’acceleration of aging.
Credit: Reiko Matsushita
Aldehydes are not only harmful to health; they also contribute to aging. This is what Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada and Tomoo Ogi discovered. Their research shows that these substances are involved in DNA damage which characterizes premature aging phenomena. People with premature aging disorders, such as AMeD syndrome, experience activity insufficient enzymes, notably ALDH2, which degrade aldehydes. These enzymes are essential for transforming aldehydes into non-toxic substances, particularly during alcohol consumption, including metabolism produces aldehydes that foie must eliminate.
Aldehydes react strongly with DNA and proteins, forming DNA-protein cross-links (DPCs) that block enzymes essential for cell proliferation and maintenance, leading to cellular dysfunction and aging. accelerated.
To explore these observations further, the team used a method called DPC-seq to study the link between aldehyde accumulation and DNA damage in patients with premature aging diseases. Their research suggests that the TCR complex, VCP/p97 and proteasome play a key role in the elimination of formaldehyde-induced CPDs, particularly in actively transcribed regions of DNA.
The implications of these findings are broad, not only for genetic diseases, but also for aging in a healthy population. Identifying aldehydes as factors contributing to aging opens new avenues for research into the mechanisms underlying premature aging diseases and for the development of potential treatments.
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