2024-03-06 23:00:00
Home > News > The intestine: friend or foe in MS? written on March 7, 2024 at 12:00 a.m. Article published in newspaper nº 121
As in all autoimmune diseases, in multiple sclerosis (MS), the immune system turns once morest part of the body. In this case, neurons and more precisely myelin, the protective sheath of nerve cables in the brain and spinal cord. Furthermore, scientists have found that the intestinal microbiota was altered in patients, but the latter influences the behavior of immune cells. Researchers therefore suspected it of being responsible for the autoimmune disorders1 observed in MS. But a recent study shows, on the contrary, that certain immune mechanisms in contact with the microbiota might slow down the progression of the disease2… It was while testing a new drug that greatly reduced the quantity of B lymphocytes (LB), a particular type of white blood cell, that scientists discovered it: thinking of reducing the autoimmune attack, the molecule on the contrary aggravated the condition of the patients. However, LBs learn to recognize intestinal bacteria abundant in patients and produce specific antibodies. During flare-ups, cells multiply and migrate to inflammatory sites in the brain. But once there, instead of attacking myelin as previously thought, the cells produce a protein, interleukin-10, which reduces neuroinflammation. This discovery therefore opens the path to therapeutic avenues for modulating the severity of MS by taking prebiotics and probiotics.
Read also Multiple sclerosis: acting on inflammation and oxidative stress
Read also Which probiotic to choose?
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