2024-01-17 02:49:00
【Health and Welfare News】 The causative factor that promotes the development of allergic skin inflammation in adulthood has been identified.
On the 17th, the research team of Professor Yoo Ji-hwan and researcher Ji-min Cha of the Department of Biomedical Sciences at Yonsei University College of Medicine and Professor Tae-gyun Kim of the Department of Dermatology at Severance Hospital announced on the 17th that exposure to symbiotic bacteria on the skin during childhood can affect the development of innate immunity, increasing the risk of developing allergic skin disease in adulthood by up to 34%. revealed.
The results of this study were published in the latest issue of the international academic journal ‘Cell Host&Microbe (IF 30.3)’.
The skin is an organ that functions as a representative barrier in our body. In particular, the epidermis of the skin is structurally in contact with the external environment, so many skin symbiotic bacteria live there. Among skin symbiotic bacteria, normal bacteria activate the skin’s immune cells from childhood. This helps maintain skin homeostasis until adulthood and promotes recovery even in the event of injury.
On the other hand, if normal bacteria do not coexist properly on the skin and the bacterial environment becomes unstable, skin inflammation, etc. may occur. For example, Staphylococcus aureus, one of the skin symbiotic bacteria of childhood, is known to proliferate on the skin and affect the development of skin inflammatory diseases such as atopic dermatitis. However, the exact mechanism of how commensal bacteria regulate the skin immune system in childhood and cause skin immune responses until adulthood has not yet been revealed.
The research team confirmed how commensal bacteria affect the skin’s immune response through experiments with germ-free mice. The expression of immunomodulators in the skin barrier and the activity of skin immune cells were analyzed by contacting germ-free mice with skin commensal bacteria.
As a result of the analysis, Staphylococcus lentus, a staphylococcus among skin commensal bacteria, inhabits the skin in the early stages of life and produces I3A (indole-3-aldehyde), which stimulates immune cells, thereby reducing the immune modulator TSLP. It was confirmed that expression was increased. As a result, the activity of type 2 innate lymphocytes, known as the main inflammation-causing cells in inflammatory skin diseases, was found to increase approximately two-fold.
Additionally, the research team confirmed that type 2 innate lymphocytes activated in childhood continue to interact with commensal bacteria and metabolites even during the growth period, increasing the risk of developing allergic skin diseases such as atopic dermatitis from 20% to a maximum of 34% in adulthood.
Professor Yoo Ji-hwan said, “Through this study, we confirmed the possibility of controlling innate immunity in adulthood by controlling exposure to commensal bacteria on the skin during childhood.” He added, “Early intervention on commensal bacteria on the skin can prevent potential allergic skin diseases.” “It is expected that we will be able to suggest a treatment strategy,” he said.
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