2023-11-15 06:01:17
Stress changes brain genes more and increases risk taking as an adult.
Entered 2023.11.15 15:00 Views 1 Entered 2023.11.15 15:00 Modified 2023.11.15 11:22 Views 1
Childhood stress has been shown to change the activation levels of more brain genes than a bump to the head. [사진= 게티이미지뱅크]From the time their children begin to walk, the biggest worry parents have is falling and hurting their head. This is because head injuries can directly affect brain function. However, from now on, we will have to pay more attention to stress management than to head injuries.
A study presented at Neuroscience 2023, the annual meeting of the American Academy of Neurology, found that childhood stress changes the activation levels of more brain genes than a bump to the head.
Researchers at Ohio State University temporarily removed newborn rats from their mothers every day for 14 days and then induced stress that mimicked the effects of negative childhood experiences, including a variety of potentially traumatic events. On day 15, a period when mice are developmentally equivalent to infants, stressed and non-stressed mice suffered head injuries similar to concussions or did not suffer head injuries, respectively, under anesthesia. Rats that only experienced stress, rats that only suffered head injury, and rats that experienced both head injury and stress were compared with rats that neither experienced stress nor suffered head injury.
The results of the study showed that mice that experienced only stress and mice that experienced head injury plus stress activated pathways of excitatory and inhibitory neurons related to plasticity, the brain’s ability to adapt to all types of changes. Although primarily intended to promote flexibility, it has sometimes had negative consequences when change is maladaptive.
Both stress and head injury also affected signaling related to oxytocin, a hormone associated with maternal behavior and social bonding. When people only experienced stress or suffered a head injury due to stress, the oxytocin pathway was activated. However, head injury alone suppressed the oxytocin pathway.
In behavioral experiments with adult rats, only animals that experienced stress early in life tended to enter large spaces more frequently, places that were perceived as dangerous. “Overall, this suggests more risk taking later in life, which suggests that early life stress may increase the risk of certain disorders, such as ADHD, which can be characterized by risk-taking behavior or substance use disorders,” the researchers said. “It is consistent with human data,” he explained.
“We found that more and more genes were differentially expressed as a result of manipulation of early stress than manipulation of traumatic brain injury,” the researchers said. “Stress is truly powerful, and the impact of early life stress on brain development should not be underestimated. Can not be done. “Stress tends to be ignored, but it is a very important public health topic.”
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