2023-09-06 06:00:05
Researchers have just identified that a drug commonly used to fight cancer might prove effective in killing “silent” HIV cells.
Image d’illustration Pixabay
HIV affects 39 million people worldwide. To this day (The day or day is the interval which separates sunrise from sunset; it is the…) still, this virus (A virus is a biological entity which requires a host cell, which it uses …) cannot be completely eradicated because it generates a latent infection. HIV-positive people are forced to receive lifelong antiretroviral treatment, which is highly effective but ineffective. unfortunately not to reach the so-called “silent” infected cells. Thus, the patient (In the field of medicine, the term patient commonly refers to a person receiving…) is never completely cured, because the virus remains present in his body. If this treatment is stopped, the cells infected by the virus in “hibernation” reactivate very quickly. Australian researchers from the WEHI Institute and the Doherty Institute recently detected that Venetoclax, a drug commonly used once morest leukemia (Leukemia (of Greek leukos, white, and haima, blood), or leucosis, is a cancer of cells…), had the effect of delaying the reappearance of the virus by 2 weeks, even without taking antiretroviral treatment. They also discovered that, combined with another drug, this treatment might be effective over a longer period of time. Furthermore, the tests carried out reveal that taking Venetoclax might also reduce the quantity of HIV DNA in the patient’s cells. . This drug would thus have the ability to target infected cells to kill them.
A first clinical trial will begin this end of the year (A year is a unit of time expressing the duration between two occurrences of a related event…) in Denmark in order to evaluate the safety and tolerability of this treatment associated with suppressive antiretroviral treatment. Let us hope that the results of future trials will be as positive and can further improve current treatments.
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